The Investigation of NT-proBNP Values in Third-Trimester Gestational Diabetes Women Without Cardiovascular Disease

NT-proBNP Values in Gestational Diabetes

Abstract

Objective: The clinical utility and importance of natriuretic peptides during pregnancy in women with gestational diabetes mellitus (GDM) and no known cardiovascular disease are not well-known. We aimed to investigate N-terminal pro-B-type natriuretic peptide (NT-proBNP) values in women with gestational diabetes in the third trimester without cardiovascular disease.
Methods: This study included pregnant women in the third trimester who were referred to our outpatient cardiology clinic for dyspnea assessment between August and September 2024. Patients were classified into two groups: the GDM group (n = 31) and the control group (n = 20). NT-proBNP values and clinical and laboratory parameters were compared between the two groups.
Results: No differences were observed between the two groups with respect to age, height, weight changes during pregnancy, or biochemical and echocardiographic parameters. Weight and body mass index were significantly elevated in the GDM group. NT-proBNP values were higher in the GDM group than in the control group. However, there were no statistically significant differences in NT-proBNP values between the two groups [28.9 (4–258) pg/mL vs. 18 (4–230) pg/mL, p = 0.331].
Conclusion: We found that NT-proBNP values were similar in gestational and non-gestational pregnant women in the third trimester without cardiovascular disease.