Malignancy and Complication Rate in Reoperation of Recurrent Goiter
Abstract
Objective: The aim of this study was to evaluate the fine needle aspiration biopsy findings of recurrent goiter patients who were operated subtotally or lobectomised for benign causes, and to determine the malignancy and complication rates for those who were reoperated.
Methods: Between 2008 and 2009, 114 patients diagnosed with recurrent goiter were involved in this study. The cytological findings of 158 nodules and histological findings of 18 patients with reoperation were examined. The complications of primary surgery and reoperation of recurrent goiter were determined.
Results: The operation indications were euthyroid multinodular goiter in 106 of the patients and toxic multinodular goiter in 8 of them. The average time elapsed from the time of the first operation was 16.5±7.5 years. The patients with a fine needle aspiration biopsy resulted in 6 with suspicion of malignancy, 3 with malignancy, 5 with hurtle cell cytology, 7 with cellular microfollicular lesion, 1 patient with toxic multinodular goiter and 2 with inadequate cellular cytology; a total of 24 patients (21%) were asked for reoperation. Among the 18 patients who accepted reoperation, pathology results discovered 2 papillary microcarcinomas and 2 papillary thyroid carcinomas. A total of 7 of the 18 patients with reoperation had surgical complications: 3 had vocal cord paralysis and 4 had hypoparathyroidism.
Conclusion: In our study, we found that a high rate of recurrent goiter patients required reoperation and there was a considerable amount of complication rate of reoperative thyroid surgery. To eliminate the potential risk of reoperation, we recommend a total thyroidectomy instead of subtotal thyroidectomy or lobectomy as the surgery of choice for the primary surgery with benign indications.
References
Chen H, Dudley N, Westra W, Sadler G, Udelsman R. Utilization of fine-needle aspiration in patients undergoing thyroidectomy at two academic centers across the Atlantic. World J Surg. 2003; 27: 208–11.
Lang BHH, Lo CY. Total thyroidectomy for multinodular goiter in the elderly. Am J Surg. 2005; 190: 418–23.
Torre G, Barreca A, Borgonovo G, Minuto M, Ansaldo GL, Varaldo E, et al. Goiter recurrence in patients submitted to thyroid-stimulating hormone suppression: possible role of insulin-like growth factors and insulin-like growth factor-binding proteins. Surgery. 2000, 127: 99–103.
Kraimps JL, Marechaud R, Gineste D, Fieuzal S, Metaye T, Carretier M, et al. Analysis and prevention of recurrent goiter. Surg Gynecol Obstet. 1993; 176: 319–322
Seiler CA, Glaser C, Wagner HE. Thyroid gland surgery in an endemic region. World J Surg. 1996; 20: 593-6.
Agarwal G, Aggarwal V. Is total thyroidectomy the surgical procedure of choice for benign multinodular goiter? An evidence-based review. World J Surg. 2008; 32:1313-24.
Moalem J, Suh I, Duh QY. Treatment and prevention of recurrence of multinodular goiter: an evidence-based review of the literature. World J Surg. 2008; 32: 1301-12.
Vasica G, O'Neill CJ, Sidhu SB, Sywak MS, Reeve TS, Delbridge LW. Reoperative surgery for bilateral multinodular goiter in the era of total thyroidectomy. Br J Surg. 2012; 99:688-92.
Schmitz-Winnenthal FH, Schimmack S, Lawrence B, Maier U, Heidmann M, et al. Quality of life is not influenced by the extent of surgery in patients with benign goiter. Langenbecks Arch Surg. 2011; 396:1157-63.
Ozbas S, Kocak S, Aydintug S, Cakmak A, Demirkiran MA, Wishart GC. Comparison of the complications of subtotal, near total and total thyroidectomy in the surgical management of multinodular goiter. Endocr J. 2005; 52: 199-205.
Bauer PS, Murray S, Clark N, Pontes DS, Sippel RS, Chen H. Unilateral thyroidectomy for the treatment of benign multinodular goiter. J Surg Res. 2013; 184: 514-8.
Gaitan E, Nelson NC, Poole GV. Endemic goiter and endemic thyroid disorders. World J Surg. 1991; 5: 205–15.
Muller PE, Jakoby R, Heinert G, Spelsberg F. Surgery for recurrent goitre: its complications and their risk factors. Eur J Surg. 2001; 167: 816–21.
Erdogan G, Erdogan MF, Emral R, Baştemir M, Sav H, Haznedaroğlu D, et al. Iodine status and goiter prevalence in Turkey before mandatory iodization. J Endocrinol Invest. 2002; 25: 224-8.
Müller PE, Kabus S, Robens E, Spelsberg F. Indications, Risks, and Acceptance of Total Thyroidectomy for Multinodular Benign Goiter. Surg Today. 2001; 3: 958-62.
Korun N, Asci C, Yilmazlar T, Duman H, Zorluoglu A, Tuncel E, et al. Total thyroidectomy or lobectomy in benign nodular disease of the thyroid: changing trends in surgery. Int Surg. 1997; 82: 417-9.
Pappalardo G, Guadalaxara A, Frattaroli FM, Illomei G, Falaschi P. Total compared with subtotal thyroidectomy in benign nodular disease: personal series and review of published reports. Eur J Surg. 1998; 164: 501-6.
Liu Q, Djuricin G, Prinz RA. Total thyroidectomy for benign thyroid disease. Surgery. 1998; 123: 2-7.
Fritzsche H. Die resezierte Struma: Diagnose, Rezidivprophylaxe, Therapie. Acta Med Austr. 1982; 34: 33-8.
Goretzki P, Roecher HD, Horeyseck G. Prophylaxis of recurrent goiter by high dose L – tyroxine. World J Surg. 1981; 5: 855-7.
Kologlu S, Bascal N, Kologlu LB. The value of L-thyroxine in the suppressive therapy of euthyroid nodules and in the prevention of post thyroidectomy recurrences. Rom J Med. 1988; 26: 89-98.
Torre G, Barreca A, Borgonovo G, Minuto M, Ansaldo GL, Varaldo E, et al. Goiter recurrence in patients submitted to thyroid-stimulating hormone suppression: possible role of insulin-like growth factors and insulin-like growth factor-binding proteins. Surgery. 2000; 127: 99-103.
Harrer P, Broecker M, Zint A, Schatz H, Zumtobel V, Derwahl M. Thyroid nodules in recurrent multinodular goiters are predominantly polyclonal. J Endocrinol Invest. 1998; 21: 380-5.
Studer H, Derwahl M. Mechanism of non-neoplastic endocrine hyperplasia – a changing concept: a review focused on the thyroid gland. Endocr Rev. 1995; 16: 411-26.
Piraneo S, Vitri P, Galimberti A, Guzzetti S, Salvaggio A, Bastagli A. Recurrence of goiter after operation in euthyroid patients. Eur J Surg. 1994; 160: 351-6.
Kraimps JL, Marechaud R, Gineste D, Fieuzal S, Metaye T, Carretier M, et al. Analysis and prevention of recurrent goiter. Surg Gynecol Obstet. 1993; 176: 319-22.
Pappalardo G, Guadalaxara A, Frattaroli FM, Illomei G, Falaschi P. Total compared with subtotal thyroidectomy in benign nodular disease: personal series and review of published reports. Eur J Surg. 1998; 164: 501-6.
Bononi M, de Cesare A, Atella F, Angelini M, Fierro A, Fiori E et al. Surgical treatment of multinodular goiter: incidence of lesions of the recurrent nerves after total thyroidectomy. Int Surg. 2000; 85: 190-3.
Pironi D, Panarese A, Candioli S, Manigrasso A, La Gioia G, Romani AM, et al. Reoperative thyroid surgery: personal experience and review of the literature. G Chir. 2008; 29: 407-12.
Lefevre JH, Trsallet C, Leenhardt L, Jublanc C, Chigot JP, Menegaux F. Reoperative surgery for thyroid disease. Surg. 2007; 392: 685-91.
Shara AR.Revision thyroid surgery - technical considerations. Otolaryngol Clin North Am. 2008;41:1169-83.
Dener C. Complication rates after operations for benign thyroid disease. Acta Otolaryngol. 2002; 122: 679–83.
Colak T, Akca T, Kanik A, Yapici D, Aydin S. Total versus subtotal thyroidectomy for the management of benign mutlinodular goiter in an endemic region. ANZ J Surg. 2004; 74:974–8.
Meneqaux F, Leenhaedt L, Dahman M, Schmitt G, Aurengo A, Chigot JP. Repeated thyroid surgery, indications and results. Presse Med. 1997; 26: 1850-4.