The Role of Childhood Traumas in Adult Hashimoto’s Thyroiditis


  • Uğur Aydoğan Etlik City Hospital
  • Hüseyin Demirci Etlik City Hospital
  • Ebru Aydoğan Hacettepe University Hospital


Autoimmune thyroiditis, Hashimoto's thyroiditis, childhood traumas


Objective: Hashimoto’s thyroiditis (HT) is the most common
autoimmune thyroid disease. There are studies suggesting that
childhood traumas cause hypothalamic-pituitary-adrenal axis
dysfunction in adulthood, which predisposes patients to autoimmune
diseases. Our study aimed to investigate the relationship between HT
and childhood trauma.
Methods: In our study, we included 52 patients diagnosed with HT
and 31 healthy controls and evaluated the Turkish Childhood Trauma
Questionnaire (which evaluates childhood traumas retrospectively)
in both groups. The diagnosis of HT was confirmed using anti-thyroid
peroxi-dase (anti-TPO) levels and thyroid ultrasonography.
Results: The childhood emotional neglect score (10.79±3.90) was
significantly higher in pa-tients with HT than in the control group
(p=0.04). However, no significant difference was ob-served between
the two groups regarding other components. In addition, a significant
positive correlation was found between anti-TPO levels and emotional
neglect score (p=0.02; r=0.26).
Conclusion: The significantly higher emotional neglect score in
patients with HT compared with the control group and the positive
correlation between childhood emotional neglect score and anti-TPO
level suggest that childhood traumas may play a role in the etiology of
adult HT. Further and large-scale studies are needed to elucidate all
aspects of this subject.

Author Biographies

Uğur Aydoğan, Etlik City Hospital

Uğur Aydoğan, MD

Ankara Etlik City Hospital, Intensive Care Department

Koru Mah. Kavaklı Sk. KoruGül blok no:3A/53 Çankaya/Ankara

Tel: +90 5052729286

ORCID no: 0000-0002-8942-9991

Hüseyin Demirci, Etlik City Hospital

Hüseyin Demirci, MD

Ankara Etlik City Hospital, Endocrinology and Metabolism Department

ORCID no: 0000-0003-0737-2360

Ebru Aydoğan, Hacettepe University Hospital

Ebru Aydoğan, MD

Hacettepe University Hospitals, Public Health Department

ORCID no: 0009-0005-7939-742X



31.12.2023 — Updated on 24.01.2024




Original Research