Prevalence of Autoimmune Thyroiditis and Other Autoimmune Diseases in Relation to Serum BAFF/APRIL Levels in Prolactinoma Patients: Prevalence of Autoimmune Thyroiditis and Other Autoimmune Diseases in Relation to Serum BAFF/APRIL Levels in Prolactinoma Patients

Authors

Özlem Kanburoğlu Meletli Gazi University Faculty of Medicine, Department of Internal Medicine, Ankara, Türkiye
Alev Altınova Gazi University Faculty of Medicine, Department Endocrinology and Metabolism, Ankara, Türkiye
Başak Bolayır Gazi University Faculty of Medicine, Department Endocrinology and Metabolism, Ankara, Türkiye
Resul Karakuş Gazi University Faculty of Medicine, Department of Immunology, Ankara, Türkiye
Meriç Coşkun Gazi University Faculty of Medicine, Department Endocrinology and Metabolism, Ankara, Türkiye
Mehmet Muhittin Yalçın Gazi University Faculty of Medicine, Department Endocrinology and Metabolism, Ankara, Türkiye
Müjde Aktürk Gazi University Faculty of Medicine, Department Endocrinology and Metabolism, Ankara, Türkiye
İlhan Yetkin Gazi University Faculty of Medicine, Department Endocrinology and Metabolism, Ankara, Türkiye
Füsun Saadet Toruner Gazi University Faculty of Medicine, Department Endocrinology and Metabolism, Ankara, Türkiye

Keywords:

Prolactinoma, autoimmune thyroiditis, vitamin B12, BAFF, APRIL, quality of life, anxiety, depression

Abstract

Objective: There may be an association between hyperprolactinemia and autoimmune diseases, possibly because of the immunostimulatory effect of prolactin. The aim of this study was to investigate the prevalence of thyroid and non-thyroid autoimmune diseases, serum B-cell activating factor (BAFF), and proliferation- inducing ligand (APRIL) levels as indicators of increased autoimmunity, quality of life, depression, and anxiety in patients with prolactinoma.

Methods: Fifty-six premenopausal women with prolactinoma and 50 healthy premenopausal women were included in the study. Autoimmune markers, including anti-nuclear antibody, rheumatoid factor immunoglobulin M (IgM) (RF-IgM), anti-double-stranded DNA (anti-dsDNA), anti-transglutaminase IgA (anti TG-IgA), and anti-Sjogren’s syndrome A (anti-ssA), serum BAFF, APRIL and vitamin B12 levels, thyroid function tests, anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin and thyroid Doppler ultrasound, were evaluated. Short-form 36, Beck Depression Inventory, and Beck Anxiety Inventory tests were also used.

Results: The prevalence of autoimmune thyroiditis (AIT) was 32.1% in the patient group, whereas the prevalence of newly diagnosed AIT was similar to controls (p>0.05). Vitamin B12 deficiency was higher in patients with prolactinoma than in controls (25.6% and 9.1%, p=0.016). Autoantibody positivity was found to be similar between the groups (35.7% and 28.1%, p=0.25). Serum BAFF and APRIL levels were not different in patients with prolactinoma than in controls (p>0.05). Quality of life, anxiety, and depression scores were not different between patients with or without AIT and those with or without positivity for any autoantibody (p>0.05).

Conclusion: One-third of the patients were diagnosed with AIT and one-fourth of the patients had vitamin B12 deficiency in our study. However, non-thyroid autoimmune diseases did not increase and no alterations were detected in serum BAFF/APRIL levels in patients with prolactinoma.

Prevalence of Autoimmune Thyroiditis and Other Autoimmune Diseases in Relation to Serum BAFF/APRIL Levels in Prolactinoma Patients