The Importance of Iron, Copper, Zinc, and Magnesium Dyshomeostasis in terms of Alzheimer’s Disease and Possible Mechanisms

The Importance of Iron, Copper, Zinc, and Magnesium Dyshomeostasis in terms of Alzheimer’s Disease and Possible Mechanisms

Authors

  • Esra Tekin Kütahya Health Sciences University Faculty of Medicine, Department of Physiology, Kütahya, Türkiye
  • Ayşegül Küçük Kütahya Health Sciences University Faculty of Medicine, Department of Physiology, Kütahya, Türkiye
  • Mustafa Arslan Kütahya Health Sciences University Faculty of Medicine, Department of Physiology, Kütahya, Türkiye

Keywords:

Alzheimer’s disease, dyshomeostasis, iron, copper, zinc, magnesium

Abstract

Alzheimer’s disease (AD) affects many people around the world, and its incidence is increasing. In addition to the amyloid cascade hypothesis, different mechanisms are discussed for AD, which has no definitive treatment. Studies have shown that the levels of metal cations such as iron, copper, zinc, and magnesium vary and their metabolism are impaired in patients with AD. Metal cation dyshomeostasis is believed to be one of the mechanisms that contribute to the development of AD. In this review, we aimed to evaluate various metal cations in terms of AD.

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Published

29.12.2023

Issue

Vol. 35 No. 1 (2024): Gazi Medical Journal

Section

Review

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