Effects of Recurrent Sevoflurane Anesthesia on Erythrocyte Deformability in Experimentally Induced Alzheimer Rats

Authors

Ayşegül Küçük Kütahya Health Sciences University, School of Medicine, Department of Physiology, Kütahya
Faruk Metin Çomu Kırıkkale University, School of Medicine Department of Physiology, Kırıkkale
Şevin Güney Gazi University, School of Medicine Department of Physiology, Ankara
Fatmanur Duruk Erkent Hitit University, School of Medicine Erol Olçok Education and Research Hospital, Department of Anesthesiology and Reanimation, Çorum
Berrin Işık Gazi University, School of Medicine, Department of Anesthesiology and Reanimation, Ankara
Levent Öztürk Yıldırım Bayazit University School of Medicine, Department of Anesthesiology and Reanimation, Ankara
Mustafa Arslan Gazi University, School of Medicine, Department of Anesthesiology and Reanimation, Ankara

Abstract

Objectives: The aim of this study was to investigate the association between Alzheimer's disease and erythrocyte deformability and to assess whether recurrent sevoflurane anesthesia influenced this association.

Methods: A total of 24 Wistar albino rats were divided into four groups: Control, sevoflurane, Alzheimer, and Alzheimer + sevoflurane. The experimental Alzheimer model was prepared by intracerebroventricular injection of streptozotocin at a dose of 3 mg/kg (10 μl) to the Alzheimer and Alzheimer + sevoflurane groups. Sevoflurane (2.3%) was administered to the sevoflurane and Alzheimer + sevoflurane groups 4 weeks after the surgery for 3 days and lasting for 2 hours per day. Blood samples were then collected for deformability measurements.

Results: The deformability index was significantly increased in Alzheimer-induced rats, but the results for the Alzheimer and Alzheimer + sevoflurane groups were similar. The erythrocyte deformability index was significantly increased in the Alzheimer and Alzheimer + sevoflurane groups (p=0.004 p=0.001 respectively). However, there was no difference in deformability in the sevoflurane group (p= 0.496)

Conclusion: Erythrocyte deformability was increased in the Alzheimer-induced rats; however recurrent sevoflurane anesthesia did not affect erythrocyte deformability.

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Published

15.12.2021

Issue

Vol. 33 No. 1 (2022): Gazi Medical Journal

Section

Original Research