Determination of Nutritional Status Via Food Frequency Consumption (FFQ) and Serum Proteins and Anemia Parameters in Multiple Sclerosis (MS) Patients

  • Gamze Akbulut Gazi University
  • Gurdal Orhan
  • Erdem Gurkas
  • Nevin Sanlier
  • Makbule Gezmen-Karadag
  • Yesim Sucullu Karadag
  • Hilal Yildiran
  • Fikri Ak
Keywords: Multiple sclerosis, nutrition, albumin, prealbumin, haemoglobin, iron, vitamin B12, folic acid

Abstract

Objectives: The study was aimed to determine the nutritional status, serum proteins (total protein, albumin, prealbumin) and some anemia parameters (haemoglobin, iron, vitamin B12, homocysteine) of the Multiple Sclerosis (MS) patients. Methods: It was conducted on 63 MS patients (41 female, 22 male) who have applied to Ankara Numune Education and Research Hospital, Department of Neurology, Turkey. Some anthropometric and biochemical measurements were taken from the study group. Nutritional status was assessed by food frequency consumption results. Results: The Relapsing/Remitting Multiple Sclerosis (RRMS) was mostly seen in both genders (90.5%). The mean age was found 34.9±8.59 (20-56) years in the study group. The mean body mass index (BMI) was found as 25.2±4.86 kg/m2. While the mean albumin (p=0.021), prealbumin (p=0.005), homocystein (p=0.007), haemoglobin (p<0.001) levels were found to be significantly high; the vitamin B12 measurement (p=0.025) was low in males. The consumption of cheese, red meat, white bread, sugar and carbonated drinks decreased after the diagnosis period in females (p>0.05). There was no change in the consumption of egg, chicken, legumes, vegetable, fruit, margarine, butter and olive oil. Most of the two groups have consumed fish rarely before and after the diagnosis of MS. Conclusion: It was concluded that nutritional status of MS patients improved after diagnosis and serum proteins which also indicate that adequate and balanced nutrition were in desired levels. 

References

Buchter B, Dunkel M, Li J. Multiple Sclerosis: A Disease of Affluence? Neuroepidemiology 2012;39:51-6.

Castro-Borrero W, Graves D, Frohman TC, Flores AB, Hardeman P, Logan D, et al. Current and emerging therapies in multiple sclerosis: a systematic review. Ther Adv Neurol Disord 2012;5:205-20.

Coo H, Aronson KJ. A systematic review of several potential non-genetic risk factors for multiple sclerosis. Neuroepidemiology 2004;23:1-12.

de Benoist B. Conclusions of a WHO technical consultation on folate and vitamin B12 deficiencies. Food Nutr Bull 2008;29(Suppl):238-44.

Habek M, Hojsak I, Brinar VV. Nutrition in multiple sclerosis. Clin Neurol Neurosurg 2010;112:616-20.

Hersh C, Rae-Grant A. Extended-release dalfampridine in the management of multiple-sclerosis-related walking impairment. Ther Adv Neurol Disord 2012;5:199-204.

Kim K, Reicks M, Sjoberg S. Applying the theory of planned behavior to predict dairy product consumption by older adults. J Nutr Educ Behav 2003; 35,294–301.

Lohman TG, Roche AF, Martorell R. Anthropometric Standardization Reference Manual. Kinetics Books, Champaign, Illinois. 1998; pp. 1-50.

McCombe PA, Greer JM. Female reproductive issues in multiple sclerosis. Mult Scler 2013;19:392-402.

Mirza M. The etiology and the epidemiology of multiple sclerosis. Erciyes Medical Journal 2002;24:40-7.

Moghtaderi A, Rakhshanizadeh F, Shahraki-Ibrahimi S. Incidence and prevalence of multiple sclerosis in southeastern Iran. Clin Neurol Neurosurg 2012; Epub ahead of print.

Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 2007;85:193-200.

Olerup O, Hillert I, Fredrikson S, Olsson T, Kam-Hansen S, Möller E, et al. Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities. PNAS 1989;86:7113-17.

Ruiz-Santana S, Arboleda Sánchez JA, Abilés J. Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE). [Guidelines for specialized nutritional and metabolic support in the critically-ill patient. Update. Consensus of the Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE): nutritional assessment]. Med Intensiva. 2011;35 Suppl 1:12-6.

Saka M, Saka M, Koseler E, Metin S, Bilen S, Aslanyavrusu M, et al. Nutritional status and anthropometric measurements of patients with multiple sclerosis. Saudi Med J 2012;33:160-6.

Salemi G, Gueli MC, Vitale F, Battaglieri F, Guglielmini E, Ragonese P, et al. Blood lipids, homocysteine, stress factors, and vitamins in clinically stable multiple sclerosis patients. Lipids Health Dis. 2010;9:19.

Schwarz S, Leweling H. Multiple sclerosis and nutrition. Mult Scler 2005;11:24–32.

Shine JW. Microcytic anemia. Am Fam Physician 1997;55:2455–62.

Valenzuela-Landaeta K, Rojas P, Basfi-Fer K. Nutritional assessment for cancer patient. Nutr Hosp. 2012;27:516-23.

WHO/FAO. Diet, Nutrition and the Prevention of Chronic Diseases, WHO Technical Report Series, 916, Geneva, 2003.

WHO/UNICEF/UNU. Iron deficiency anaemia assessment, prevention, and control: a guide for programme managers. Geneva, Switzerland: World Health Organization, 2001.

Williams CM, Lines CM, McKay EC. Iron and zinc status in multiple sclerosis patients with pressure sores. Eur J Clin Nutr 1988;42,321-8.

Published
2014-10-26
Section
Original Research