Nasopharyngeal Carcinoma with Generalized Lymphadenopathy and Hematological Abnormalities Masquerade as Lymphoma: A Case Series of Atypical Presentations and Prognostic Significant

Nasopharyngeal Carcinoma with Generalized Lymphadenopathy and Hematological Abnormalities

Abstract

Nasopharyngeal carcinoma (NPC) is a unique type of head and neck squamous cell carcinoma, characterized by distinct etiology, epidemiology, and biological characteristics. Neck swelling is the most common presenting symptom, but generalized lymphadenopathy involving other parts of the body is rarely reported. Severe anemia, leukocytosis, and thrombocytopenia are rare but may occur at an advanced stage. The combination of these atypical presentations leads to the more common diagnosis of lymphoma instead of NPC. In addition, the hematological derangements are indicators of a poor prognosis. The clinician should be aware of these atypical presentations to avoid delays in management and worsening of overall survival.