A General Overview to the Mesenchymal Stem Cell Therapies in Drug and Chemical Induced Liver Injury Models

Abstract

Liver injury is seen commonly in population depending on the drug and chemical usage. Different groups of drugs and chemical lead different pathogeneses in liver such as necrosis, fibrosis or inflammation. Although the liver has a high regenerative capability, drug and chemical-induced liver injury may be resulted in organ failure. Due to the limitations of liver transplantation, therapy methods alternative to organ transplantation still need to be studied. Owing to their differentiation and regeneration abilities, mesenchymal stem cells have recently drawn attention as potential therapeutic agents. In this review, we focused on the effects of human MSCs derived from adipose tissue, bone marrow, umbilical cord, placenta and amniotic membrane on drug and chemical-induced liver injury models. Recent studies report recovery by the application of human MSCs from different sources. Although MSC therapy leads to amelioration in liver functions, researchers still try to improve the therapeutic efficacies. To that end, different modifications and application modalities of MSCs were investigated on drug-induced liver injury models. In order to understand the molecular mechanisms of MSCs’ effects on liver injury, animal studies are required to drive research perspective for future progress.