Retrospective Research of Clinical and Hematological Changes Occurred by del Nido Cardioplegia in the Perioperative Period of Patients who Underwent Open-Heart Surgery

del Nido Cardioplegia in the Perioperative Period of Patients who Underwent Open-Heart Surgery

Abstract

Objective: Aortic cross-clamping and postischemic myocardial dysfunction are fundamentally related to myocardial protection during open-heart surgery. Various cardioplegia solutions have been developed because of this issue. del Nido cardioplegia (DNC) solution is one of these solutions and has a vital impact on metabolic markers and cardiac protection in individuals of all ages. This study aimed to examine the effects of DNC on the perioperative follow-up period after cardiac surgery.
Methods: Preoperative and postoperative variations in selected biochemical and hematological variables of 71 patients who underwent open-heart surgery in our medical faculty between 2018 and 2020 were retrospectively examined and compared with normal values. SPSS 20.0 statistical software was used, and a statistically significant difference was defined as p<0.05.
Results: Hemoglobin, platelet, albumin, and uric acid levels were significantly lower at the end of cardiopulmonary bypass and the postoperative 24th hour than in the preoperative period. At the end of the cardiopulmonary bypass and the postoperative 24th hour, aspartate aminotransferase and lactate dehydrogenase levels were significantly greater than those in the preoperative period. Remarkable increases in hemoglobin, albumin, urea, and platelets in the postoperative 24th hour compared with the end of cardiopulmonary bypass were noted. We also reported substantial differences in glucose, lactate, creatine kinase-MB, and troponin levels.
Conclusion: We found significant changes in different parameters critical for the perioperative period of open-heart surgery. Although our study found DNC to be a safer option, additional research into clinical usage is required.