Appendiceal Goblet Cell Carcinoid: An Unexpected Histology Following Simple Appendicectomy

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Rosli Ismail
Mohd Firdaus Che Ani
Salahuddin Baharom
Nornazirah Azizan
Andee Dzulkarnaen Zakaria
Firdaus Hayati

Abstract

Goblet cell carcinoid (GCC) is an enigmatic and rare tumour involving the appendix almost exclusively. It is a rare, aggressive subtype of appendiceal tumours with neuroendocrine features, and controversy exists with regards to therapeutic strategy. We herein highlight a 56-year-old lady with GCC whom she presented initially with a typical presentation of acute appendicitis. The histologic hallmark of this entity is the presence of clusters of goblet cells in the lamina propria or submucosa stain for various neuroendocrine markers, though the intensity is often patchy. GCC of the appendix is rare and challenging. In advanced form, it can present with carcinoid symptoms but occasionally mimics classical presentations of acute appendicitis. A tumour measuring less than 1 cm and located at the tip of the appendix is sufficient for a simple appendicectomy which warrants a promising prognosis.

Article Details

Section
Case Report
Author Biographies

Rosli Ismail, Department of Surgery, Selayang Hospital, Ministry of Health Malaysia, Batu Caves, Selangor, Malaysia

Department of Surgery, Selayang Hospital, Ministry of Health Malaysia, Batu Caves, Selangor, Malaysia

Mohd Firdaus Che Ani, Department of Surgery, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Sungai Buloh Campus, Selayang, Selangor, Malaysia

Department of Surgery, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Sungai Buloh Campus, Selayang, Selangor, Malaysia

Salahuddin Baharom, Department of Surgery, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Sungai Buloh Campus, Selayang, Selangor, Malaysia

Department of Surgery, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Sungai Buloh Campus, Selayang, Selangor, Malaysia

Nornazirah Azizan, Department of Pathology and Microbiology, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia

Department of Pathology and Microbiology, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia