Audiological Findings in Autoimmune Hepatitis: Hearing Loss at High Frequencies

Authors

  • Mehmet Düzlü Gazi University Faculty of Medicine, Department of Otorhinolaryngology, Ankara, Turkey
  • Mustafa Çolak Ankara Numune Training and Research Hospital, ENT Clinic, Ankara, Turkey
  • İbrahim Koral Önal Gazi University Faculty of Medicine, Department of Gastroenterology, Ankara, Turkey
  • Hakan Tutar Gazi University Faculty of Medicine, Department of Otorhinolaryngology, Ankara, Turkey
  • Recep Karamert Gazi University Faculty of Medicine, Department of Otorhinolaryngology, Ankara, Turkey
  • Çağıl Gökdoğan Gazi University Faculty of Medicine, Department of Audiology, Ankara, Turkey

Abstract

Objectives: In this study we aimed to examine the audiological findings in autoimmune hepatitis (AIH). Patients and Methods: Nine patients with the diagnosis of AIH were included in the study. Eighteen healthy age and sex matching volunteers constituted the control group. All the subjects underwent audiologic evaluation with pure tone and speech audiometry. Results: Pure tone air conduction threshold averages for right ears in study and control group were 10.14 ± 4.70 and 6.73 ± 1.43 dB, respectively (p=0.022). Pure tone air conduction threshold averages for left ears in study and control group were 10.42 ± 4.84 and 6.66 ± 1.35 dB, respectively (p=0.018). There was significant decline at high frequencies (4000, 6000 and 8000 Hz) in AIH group compared to healthy controls (p<0.05). Speech reception thresholds and speech discrimination percentages were also significantly decreased in AIH (p<0.05). Conclusion: In conclusion, this is the first study in the literature showing the presence of hearing loss in AIH. However further studies with larger groups and including other assessment tools such as OAE are needed.

References

Mijovic T, Zeitouni A, Colmegna I. Autoimmune sensorineural hearing loss: the otology-rheumatology interface. Rheumatology 2013;52:7809.

Agrup C.Immune-mediated audiovestibular disorders in the paediatric population: a review. Int J Audiol 2008; 47:560-5.

Ruckestein MJ. Autoimmune inner ear disease. Curr Opin Otolaryngol Head Neck Surg 2004;12:426-30.

McCabe BF. Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol 1979; 88:585-9.

Pascual-Ramos V, Contreras-Yáñez I, Enríquez L, Valdés S, Ramírez-Anguiano J. Hearing impairment in a tertiary-care-level population of Mexican mestizo rheumatoid arthritis patients: frequency, characteristics and prognosticators. J Clin Rheumatol 2012; 18:393-8.

Bayazit YA, Yilmaz M, Gunduz B, Altinyay S, Kemaloglu YK, Onder M, et al. Distortion product otoacoustic emission findings in Behçet’s disease and rheumatoid arthritis. ORL J Otorhinolaryngol Relat Spec 2007; 69: 233-8.

Andonopoulus AP, Naxakis S, Goumas P. Sensorineural hearing disorders in systemic lupus erythematosus. A controlled study. Clin Exp Rheumatol 1995; 13:137–41.

Tagboto SK, Venkatesh AG. Progressive dyspnoea following the treatment of Mycobacterium abscessus infection in an individual with relapsing granulamatosis with polyangitis (Wegener's), complicated by hearing loss requiring cochlear implantation. BMC Pulm Med. 2012; 12:47.

Wierzbicka M, Puszczewicz M, Bartochowska A, Szyfter W. The otologic manifestation of Wegener's granulomatosis--review of contemporary achievements in diagnostics and treatment. Otolaryngol Pol 2012; 66:254-8.

Kumar BN, Walsh RM, Wilson PS, Carlin WV. Sensorineural hearing loss and ulcerative colitis. J Laryngol Otol 1997; 111: 277-8.

Casellini C, Citera G, Rosemffet M, Ruggeri S, Saviotti A, Maldonado Cocco JA. Audiovestibular disorders in patients with ankylosing spondylitis. J Clin Rheumatol. 2005; 11:81-5.

Freeman SR, Sheehan PZ, Thorpe MA, Rutka JA. Ear, nose, and throat manifestations of Sjögren's syndrome: Retrospective review of a multidisciplinary clinic. J Otolaryngol 2005; 34: 20-4.

Pollak L., Luxon L.M., Haskard D.O. Labyrinthine involvement in Behçet's syndrome. J Laryngol Otol 2001; 115: 522-9.

Ndiaye IC, Rassi SJ, Wiener-Vacher S. Cochleovestibular impairment in pediatric Cogan's syndrome. Pediatrics 2002; 109: 1-7.

Liberal R, Grant CR. Cirrhosis and autoimmune liver disease: Current understanding. World J Hepatol 2016; 8:1157-68.

Liberal R, Krawitt EL, Vierling JM, Manns MP, Mieli-Vergani G, Vergani D. Cutting edge issues in autoimmune hepatitis. J Autoimmun. 2016; 75:6-19.

Manns MP, Czaja AJ, Gorham JD, Krawitt EL, Mieli-Vergani G, Vergani D, et al. Diagnosis and management of autoimmune hepatitis. Hepatology 2010; 51:2193-213.

Dikici O, Muluk NB, Tosun AK, Unlüsoy I. Subjective audiological tests and transient evoked otoacoustic emissions in patients with rheumatoid arthritis: analysis of the factors affecting hearing levels. Eur Arch Otorhinolaryngol 2009; 266:1719-26.

Ozcan M, Karakuş MF, Gündüz OH, Tuncel U, Sahin H. Hearing loss and middle ear involvement in rheumatoid arthritis. Rheumatol Int 2002; 22:16-9.

Kastanioudakis I, Skevas A, Danielidis V, Tsiakou E, Drosos AA, Moustopoulos MH. Inner ear involvement in rheumatoid arthritis: a prospective clinical study. J Laryngol Otol 1995; 109:713-8.

Downloads

Published

30.09.2017

Issue

Section

Original Research