Metastatic Cancer Versus Sarcoidosis in a Geriatric Patient: A Never-Ending Pitfall for Clinicians

Authors

  • Mustafa Kemal Kilic Gazi University Faculty of Medicine
  • Muhammet Cemal Kizilarslanoglu Gazi University Faculty of Medicine
  • Haluk Turktas Gazi University Faculty of Medicine
  • Ramazan Yildiz Gazi University Faculty of Medicine
  • Ecine Yesim Atak Gazi University Faculty of Medicine
  • Sukran Ulger Gazi University Faculty of Medicine
  • Murat Ucar Gazi University Faculty of Medicine
  • Zekeriya Ulger Gazi University Faculty of Medicine

Abstract

Sarcoidosis is a systemic disease with the multi-organ involvement. However, the lung involvement with hilar lymphadenopathy is the hallmark of the disease. Despite this, subtle clinical signs of sarcoidosis and non-spesific involvement of the chest by many different disorders often confound the diagnosis of this insidious disease. Therefore, it is essential to investigate common diseases of chest carefully before establishing the absolute diagnosis of sarcoidosis. In this article, we present a case of a 65 year-old woman who was admitted  to the hospital with a fatigue lasting six weeks, together with  a generalized body pain and left-sided chest pain propagating to the back. The patient reported anorexia with a weight loss of 4kg in this period. The initial evaluation revealed a transaminase elevation and interstitial radioopacities on the chest x-ray. The high resolution computer tomography of the chest showed the interstitial involvement and bronchiectasis. The angiotensin converting enzyme level was elevated. The bronchoalveolar lavage CD4/CD8 lymphocyte ratio was 3.39 and supported the diagnosis of sarcoidosis. The bronchoscopic biopsies were taken from airways and paratracheal lymph nodes to establish definitive diagnosis. Unlike our expectations, the biopsy revealed a breast cancer. The PET-CT, abdominal and cranial imaging showed metastases by the time of diagnosis. The trastuzumab therapy was started but the patient died as a consequence of the septic shock. 

Author Biographies

Mustafa Kemal Kilic, Gazi University Faculty of Medicine

Department of Internal Medicine, Division of Geriatric Medicine

Specialist in Internal Medicine, Geriatrics fellow 

Muhammet Cemal Kizilarslanoglu, Gazi University Faculty of Medicine

Department of Internal Medicine, Division of Geriatric Medicine

Specialist in Internal Medicine, Geriatrics fellow 

Haluk Turktas, Gazi University Faculty of Medicine

Prof M.D.

Department of Pulmonology

Ramazan Yildiz, Gazi University Faculty of Medicine

Assoc Prof M.D.

Department of Medical Oncology

Ecine Yesim Atak, Gazi University Faculty of Medicine

Department of Pathology

Resident doctor

Sukran Ulger, Gazi University Faculty of Medicine

Assoc Prof M.D.

Department of Radiation Oncology

Murat Ucar, Gazi University Faculty of Medicine

Assoc Prof M.D.

Department of Radiology

Zekeriya Ulger, Gazi University Faculty of Medicine

Assoc Prof M.D.

Department of Internal Medicine, Division of Geriatric Medicine

References

Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. The New England journal of medicine 2007;357:2153-65.

Bush E, Lamonica D, O'Connor T. Sarcoidosis mimicking metastatic breast cancer. The breast journal 2011;17:533-5.

Viswanath L, Pallade S, Krishnamurthy B, Naveen T, Preethi BL, Pramod KP, et al. Darier-Roussy Sarcoidosis Mimicking Metastatic Breast Cancer. Case reports in oncology 2009;2:251-4.

Tolaney SM, Colson YL, Gill RR, Schulte S, Duggan MM, Shulman LN, et al. Sarcoidosis mimicking metastatic breast cancer. Clinical breast cancer 2007;7:804-10.

Mingins C, Williams MR, Cox NH. Subcutaneous sarcoidosis mimicking breast carcinoma. The British journal of dermatology 2002;146:924-5.

Gallimore AP, George CD, Lampert IA. Subcutaneous sarcoidosis mimicking carcinoma of the breast. Postgraduate medical journal 1990;66:677-8.

Mona el K, Pascal C, Charley H, Francoise B, Veronique B, Marie-Madeleine P. Quiz case. Breast sarcoidosis presenting as a metastatic breast cancer. European journal of radiology 2005;54:2-5.

Ataergin S, Arslan N, Ozet A, Ozguven MA. Abnormal 18F-FDG Uptake Detected with Positron Emission Tomography in a Patient with Breast Cancer: A Case of Sarcoidosis and Review of the Literature. Case reports in medicine 2009;2009:785047.

Downloads

Published

28.03.2016

Most read articles by the same author(s)

1 2 > >>