Investigation of the Protective Effects of Acetyl L-Carnitine on Cisplatin-Induced Uterus Toxicity

  • Sermin Seyhan
  • Gulistan Sanem Saribas Gazi University
  • Neslihan Coskun Akcay
  • Seren Gulsen Gurgen
  • Seda Nur Akyol
  • Guleser Goktas
  • Ibrahim Murat Hirfanoğlu
  • Deniz Erdogan
  • Candan Ozogul
Keywords: Acetyl L-carnitine, apoptosis, caspases, cisplatin, TUNEL, uterus


Objective: The aim of the study was to investigate the prophylactic effects of acetyl L-carnitine against to uterus induced by cisplatin. Methods: Twenty-four female Wistar albino rats were divided into four groups: group I (control) was administered with saline; group II was administered with acetyl L-carnitine; group III was administered with cisplatin; group IV was pretreated with acetyl L-carnitine before cisplatin intraperitoneal injection. After 72h of cisplatin injection uterine tissue was removed. Histological and immunohistochemical investigations were performed, respectively. Results: We found that the number of TUNEL and caspases positive cells were increased in the endometrial epithelium, subepithelial connective tissue, endometrial glands and stroma in group III compare to the other groups. Furthermore inflammation and edema were observed in uterus of rats in group III. Conclusion: We can concluded that pretreatment of acetyl L-carnitine administration has protective effect on histological alteration of uterus caused by cisplatin.

Author Biography

Gulistan Sanem Saribas, Gazi University
Medicine Faculty, Department of Histology and Embryology


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Original Research