Frequency of Chromosome Disorders In Patients with Sperm Number Anomaly

Frequency of Chromosome Disorders

Abstract

Objective: Chromosome abnormalities play an important role in male infertility. The chromosome disorders rate in infertile men is higher as 5.8% when compared to the normal population (0.5%).

Methods: In our study, it was aimed to determine the frequency of cytogenetic abnormality of infertil men with abnormal sperm count and to show that rare chromosomal rearrangements can be detected by karyotyping.

Results: In our clinical practice, we detect nearly all spectrum of numerical and structural anomalies of chromosomes that are involved in infertility. It includes inversions, translocations, deletions, insertions, complex rearrangements, isochromosomes, Klinefelter syndrome, mosaicism, and 47, XYY.     

Conclussion: Our results emphasize the importance of conventional cytogenetic analysis for infertile males. Detection of rare or known chromosome abnormalities will prevent unnecessary investigations and enable to apply precisions in medicine.