Synergistic Effects of Thymoquinone and Carob Powder versus Dexamethasone in the Model of Asthma in Pregnant Rats: New Insights into their Therapeutic Effects

Protective Effect of Thymoquinone and Carob Powder on Asthmatic Pregnant Rats

Abstract

Objectives:The presence of asthma during pregnancy may pose a risk to both mother and fetus due to increased oxidative stress. In this sense, nutrition styles can be considered as a factor that regulates both events in a controlled way. The aim of this study was to reveal the strength of the effects of thymoquinone (TQ) and carob powder (CP) administration, which are known to have two different strong antioxidant effects during pregnancy, on the oxidative event in the mother with the diet management strategy. Methods: Female rats were divided into 3 groups: asthmatic pregnant group (I), asthmatic pregnant with administered by TQ and CS group (II), and asthmatic pregnant with dexamethasone group (III). Results: The co-administration of TQ and CS decreased the malondialdehyde levels, and increased nitric oxide, ascorbic acid, and glutathione levels in lung tissue. In addition, the level of some of the proinflammatory cytokines decreased in the serum. The cumulative protective effect of TQ and CS was successful in reducing inflammation in the lung. Conclusion: Administration of TQ and CS may be considered as a candidate for a new herbal blend or adjuvant for both asthmatics, pregnant and asthmatic children, given the side effects of cortisol.