Serum Bilirubin Level is Positively Correlated with Severity of Coronary Artery Disease in Patients with Non-St Elevation Acute Coronary Syndrome

Abstract

Objective: We investigated the relationship between serum bilirubin levels and severity and extent of coronary artery disease in patients with non-ST elevation acute coronary syndrome.

Methods: The files of the patients who admitted to Cardiology Department of Cerrahpasa Medical Faculty, Istanbul University between the January 2006 and December 2011 with non-ST elevation acute coronary syndrome were researched retrospectively. Patients who have no known coronary heart disease, whom an angigraphy was performed and at least one vessel found to be narrowed > %50 were included in our study. SYNTAX score was calculated. Patients were divided into 2 groups. Group 1 was defined as SX score 22.

 Results: 180 patients were appropriate for our study design. While 39 patients were not investigated for bilirubin levels, the statistical analyses of bilirubin levels were done with 141 patients. There was significant positive correlation between total bilirubin and narrowed vessel number (p=,019)(r=,200). Direct bilirubin was correlated positively with SYNTAX score (p=,011)(r=,214) and narrowed vessel number (p=,005) (r=,240).

 Conclusion: There was a significant positive correlation between serum direct bilirubin which is a marker of antioxidant mechanism and SYNTAX score.These results show that bilirubins increase in non-ST elevation acute coronary syndromes as a marker of antioxidant mechanism and could play a very important role in understanding the pathogenesis of oxidative stres related diseases better and may lead to improved treatment strategies in patients with NSTE-ACS.