Protective Effects of Curcumin and Resveratrol on Kidney Tissue against Cadmium-induced Oxidative Stress in Rats

cadmium-induced oxidative stress and antioxidant

Abstract

Introduction: Cadmium (Cd) is a well-known widespread environmental pollutant and is not rapidly excreted by the kidneys, it accumulates and causes kidney damage. This study aims to compare the effects of antioxidant curcumin and resveratrol on antioxidant defense in cadmium-induced rat kidney tissue.

Methods: In the study, 36 (200-250 gr) Wistar albino rats were divided into 6 (n=6) groups. Group 1 Control; Group 2 CdCl2; Group 3: Curcumin; Group 4: CdCl2 + Curcumin; Group 5: Resveratrol; Group 6: CdCl2 + Resveratrol was formed. At the end of the experiment, malondialdehyde (MDA), total oxidant capacity (TOC) and total antioxidant capacity (TAC) activities were measured in kidney tissues.

Results: In the CdCl2 given group, oxidative stress index (OSI), TOC, and MDA levels increased compared to the control group, and TAC values decreased (p<0.05). In the case of resveratrol or curcumin given with cadmium, TAC levels increased, MDA levels and OSI values decreased compared to the group given only cadmium (p<0.05).

Conclusion: Both resveratrol and curcumin may have protective effects in the kidneys against CdCl2-induced oxidative damage.