A Special Chromosome Imbalance “Jumping translocation of 1q” in Burkitt Lymphoma


  • Betül Turan a:1:{s:5:"en_US";s:82:"Necmetti Erbakan Üniversitesi Meram Tıp Fakültesi Tıbbi Genetik Anabilim Dalı";}
  • Emine Göktaş
  • Ayşe Gül Zamani
  • Hüseyin Tokgöz
  • Mahmut Selman Yıldırım


Chromosome 1q gain that confers clonal expansion advantage to tumor cells has been reported in many solid tissue and hematological cancers, in many different forms; sometimes as a derivative chromosome, as isochromosome, or less frequently, due to an imbalance created by a jumping translocation. Although it is known that chromosome 1q gain provide the advantage of clonal expansion to the tumor cells and is relatively common in Burkitt lymphoma/leukemia, its detection in the form of jumping translocation is extraordinarily rare and results of JT containing 1q are controversial. Bone marrow cytogenetic examination performed on a case diagnosed with stage 4 Burkitt lymphoma/leukemia resulted in 46,XY,dup(1)(q21q42),t(8;14)(q24;q32)[5]/46,XY,der(6)t(1;6)(q21;q27),t(8;14)(q24;q32)[4]/46,XY,t(8;14)(q24;q32), der(11)t(1;11)(q21;q23 )[2]/46,XY[3]. We present the clinical features of the case that was found to have 1q gain in the jumping translocation form to contribute to the literature.