Paroxysmal Autonomic Instability with Dystonia (PAID) Syndrome: A Rare Occurrence

PAID Syndrome

Authors

  • Vayara Perumall Vinodh Clinic of Neurosurgery, Hospital Tengku Ampuan Afzan, Kuantan, Pahang
  • Sivakumaran Rajandran Clinic of Neurosurgery, Hospital Queen Elizabeth II, Kota Kinabalu, Malaysia
  • Rajesh Kumar Muniandy Department of Anaesthesia and Intensive Care, Universiti Malaysia Sabah Faculty of Medicine and Health Sciences, Malaysia
  • Pulivendhan Sellamuthu Clinic of Neurosurgery, Jesselton Medical Centre, Sabah, Malaysia

Keywords:

Paroxysmal Autonomic Instability with Dystonia (PAID), Dystonia, Ventriculitis

Abstract

Paroxysmal Autonomic Instability with Dystonia (PAID) is still under-recognised in clinical settings due to its rarity. This syndrome may mimic certain life-threatening conditions. We would like to present a rare case of PAID syndrome. A 45-year-old female was brought to the hospital with an altered level of consciousness. An urgent Computed Tomography (CT) of the brain was done, and a diagnosis of obstructive hydrocephalus secondary to cerebellar hemorrhage was made. Her family refused major surgery but consented to cerebrospinal fluid diversion. However, after several days in the ward, she developed ventriculitis. She was successfully treated with intravenous ceftriaxone. After several weeks at home, she developed episodic attacks of hypertension, tachycardia, and diaphoresis with hyperthermia. She also had episodes of restlessness and generalized dystonic movements. She was diagnosed with PAID syndrome, and treatment was initiated. Her symptoms were successfully treated after three days.

Author Biography

Rajesh Kumar Muniandy, Department of Anaesthesia and Intensive Care, Universiti Malaysia Sabah Faculty of Medicine and Health Sciences, Malaysia

Medical Lecturer, Hospital UMS

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Published

15.04.2025