Platelet Indices and Coagulation Parameters in Critical Patients with Coronavirus Disease-2019

COVID-19 ile platelet indeksleri arasındaki ilişki

Abstract

Background: The coronavirus disease-2019 (COVID-19) pandemic continues to demonstrate its effects worldwide and critical patients hospitalized in intensive care units (ICUs) because of the disease are still losing their lives. In this single-center retrospective study, it was aimed to 0determine the differences in platelet indices and coagulation parameters at admission in critically ill patients in the ICU.

Methods: This study included 792 critically ill patients with COVID-19 followed in ICUs. The patients were divided into two groups as those who survived (Survivors, group S) and those who did not survive (Nonsurvivors, group NS) and were compared in terms of clinical features, APACHE II and SOFA scores,  and laboratory values at first admission to the ICU. In addition, patients were also divided into two groups as those with ≥1 comorbidity and those without comorbidities and compared in terms of platelet indices and coagulation parameters.

Results: Age, APACHE II, and SOFA scores were found to be significantly higher in group NS compared with those in group S (p<0.001). When the groups were evaluated in terms of platelet indices and coagulation parameters, it was found that the patients in group NS had higher MPV (p=0.009), P-LCR (p=0.023), and D-dimer (p=0.021) values. In addition, when the patients were divided into groups in terms of the presence of comorbidity, MPV values were found to be significantly higher in patients with comorbidities (p= 0.049).

Conclusion: Platelet indices can help determine the risk of mortality in critically ill patients with COVID-19 followed-up in the ICU.