Frequency of Total Abdominal Hysterectomy-Bilateral Salpingo-Oophorectomy (TAH-BSO) History in Women with Parkinson's Disease
Total Abdominal Histerektomi-Bilateral Salpingo-ooferektomi ve Parkinson Hastalığı
Abstract
Objective: Estrogen is thought to play a protective role in a predisposition to the Parkinson's disease (PD). It was aimed to investigate the frequency of total abdominal hysterectomy-bilateral salpingo-oophorectomy (TAH-BSO) history causing withdrawal estrogen in women with PD in this study.
Methods: The electronic records of the Movement Disorders Unit of the Neurology Department were reviewed. Female with PD were selected and compared with age-matched controls without movement disorders. The patients were divided into two groups (<45 years and ≥45 years) according to their age at TAH-BSO to investigate the effect of premature estrogen withdrawal. Characteristics of PD were evaluated in these groups.
Results: Total 675 patients and 125 controls were included. The frequency of TAH-BSO was found higher in patients (15.3%) than controls (12%) but it was not significantly (p=0.34). Age of symptom onset, disease severity and daily levodopa dose were not different in patients (n=30) with age at TAH-BSO <45 years compared with the patients (n=73) with those ≥45 years at TAH-BSO. Risk of PD was found to be slightly increased in patients aged <40 years at the time of surgery (OR=1.94, 95% CI: 0.19-19.59, p=0.57) compared with those aged 40-44 years (OR=0.39, 95% CI: 0.10-1.49, p=0.17) and >45 years (OR=1.58, 95% CI: 0.32-7.80, p=0.57).
Conclusion: The frequency of TAH-BSO history in women with PD is not different compared to the control group. Risk of PD may slightly increased in patients aged <40 years of TAH-BSO. Age of TAH-BSO did not affect the analyzed clinical parameters of PD.
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