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Objective: The aim of this study was to investigate the use of mean platelet volume (MPV) as a marker in the diagnosis of gastric cancer and the prognostic importance of follow-up after treatment.
Methods: A total of 296 individuals (148 healthy and 148 patients having gastric cancer) between January 2010 and July 2018 were included the study. The possible importance of MPV elevation in diagnosis and prognosis of this cancer type was evaluated.
Results: The mean MPV of the healthy participants was 8.45±0.94 fL, while the mean preoperative MPV value of the patients with gastric cancer was 10.04±0.97 fL (p<0.001). The follow-up of MPV level in the gastric cancer patients revealed a significant change (p<0.001). No crucial difference was observed in MPV level according to tumor characteristics or cancer stage (p>0.05). A significant difference in the MPV level was seen with respect to overall survival, while no significant difference was found for disease free survival (p=0.009 and p=0.353).
Conclusion: High MPV level may be warning when evaluated together with the patient’s clinical findings for the prognosis and diagnosis of gastric cancer. It is a noninvasive, simple hematology parameter that requires no additional cost and it may have even greater significance when used with other markers for gastric cancer.