A Case Series of Holoprosencephaly


  • Nur Asma Binti Sapiai Universiti Sains Malaysia
  • Juhara Haron
  • Nasibah Mohamad
  • Nur Asma Sapiai


Holoprosencephaly is congenital brain anomaly due to incomplete separation of two cerebral hemispheres. It has three subtypes which are alobar, semilobar and lobar. Degree of severity is decreased from alobar, semilobar then lobar holoprosencephaly. The embryogenesis incidence rate is 1:250. Because of spontaneous abortion, the lower occurrence rate is seen at 1:16000 in a live birth. The patient's survival rate depends on the extent of the deformity and also the type of holoprosencephaly. In this case series, we include radiological descriptions of the holoprosencephaly of all three subtypes.

Author Biography

Nur Asma Binti Sapiai, Universiti Sains Malaysia

M.D, M.Med (Rad) Lecturer/ Radiologist, Department of Radiology, School Of Medical Sciences/USM Hospital, Universiti Sains Malaysia, Health campus, 16150 Kota Bharu, Kelantan,Malaysia.




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