In Vitro Activity of Eravacycline in Combination with Colistin Against OXA-type Carbapenemase Producing Klebsiella pneumoniae Isolates

Authors

  • Hasan selçuk özger
  • Tugba Cuhadar
  • Serap Suzuk Yildiz
  • Zehra Demirbas Gulmez
  • Ozlem Guzel Tunccan
  • Ayse Kalkanci
  • Husniye Simsek
  • Zekiye Bakkaloglu
  • Murat Dizbay

Abstract

Objective: The synergistic activity of eravacycline in combination with colistin on Oxacillinase (OXA) producing carbapenem-resistant Klebsiella pneumoniae isolates (CR-Kp) was evaluated in this study.

Methods: Minimum inhibitory concentrations of meropenem were determined by the broth microdilution method. All strains screened for carbapenemase activity by PCR. Chequerboard assay and time-kill analysis were used to assess potential synergy.

Results: Synergistic activity was found in 40 % of the strains by chequerboard assay. No antagonism was detected. Comparing to colistin alone at subinhibitory concentrations synergistic and bactericidal activity was observed when it combined with eravacycline. A Similar activity was also observed in colistin-resistant CR-Kp isolates.

Conclusion: Our results indicate that Eravacycline and colistin combination may be a potential therapeutic option for the treatment of CR-Kp infections.

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Published

22.05.2021

Issue

Vol. 32 No. 2A (2021): Gazi Medical Journal Supplement

Section

Original Research

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