Asymptomatic Primary Biliary Cholangitis in a Young Patient: An Incidental Finding


  • Norhidayah Kamarudin
  • Chuan Hun Ding
  • Nurismah Md. Isa
  • Suria Hayati Md Pauzi
  • Asrul Abdul Wahab Faculty of Medicine, Universiti Kebangsaan Malaysia


Primary biliary cholangitis (PBC) is an autoimmune disease that is increasingly recognized as an important cause of chronic liver disease. Incidental diagnoses are not uncommon. We report a case of a middle-aged female with persistently elevated ALP activity. During the investigation of cholestasis, anti-mitochondrial antibodies (AMA) were detected in her serum. Ductular reaction with cholestasis was observed in the liver biopsy sample. Based on these findings, a diagnosis of PBC was established and ursodeoxycholic acid therapy was commenced. After several weeks of treatment, biochemical improvement was noted.


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