Changing Aspect in Adult Kidney Biopsies: Ten Years Single Center Experience

Abstract

Objective: Glomerular diseases can result from many inherited or acquired disorders and could lead to chronic kidney disease.  Glomerular disease frequency varies between countries. Glomerular diseases have a dynamic structure and may change over years. According to the data in Turkey, the most common glomerulonephritis is membranous nephropathy. But last published data belongs to 2014. The aim of this study is to determine the frequency of kidney biopsy proven glomerulonephritis (GN) in Turkey

Methods: Retrospective observational study was conducted in Gazi University. We evaluated 1273 native kidney biopsies from 2008 to 2017. Renal disease were divided into five major categories: primary GN, secondary GN,  tubulointerstitial nephropathies (TIN), vascular nephropathies (VN) and acute tubular necrosis (ATN).

Results: 756 (59.4%) patients had primary GN, 353 (27.7%) patients had secondary GN, 101 (7.9%) patients had TIN, 32 (2.5%) patients had VN and 31 (2.4%) patients had ATN. While, the most frequent pathological diagnosis was focal segmental glomerulosclerosis (FSGS) (31.35%), followed by membranous GN (27.65%) in primary glomerulonephritis, amyloidosis (27.2%) was the most frequent pathological diagnosis followed by systemic lupus erythematosus (SLE) (20.68%) in secondary glomerulonephritis. FSGS is the most common kidney pathology until 50 years old (18-30 years old, 22% and 31-50 years old, 20%). Membranous glomerulonephritis (MGN) is the most common kidney pathology after the ages 50 years old (50-64 years old, 20% and >65 years old, 17%).

Conclusion: FSGS is the most common primary GN in Turkish population and the frequency is gradually increasing.