Are Peripheral Blood Derived Inflammation Markers Prognostic Indicators in Breast Cancer?

Authors

  • Hande Köksal Sağlık Bilimleri University,
  • Emet Ebru Nazik Sağlık Bilimleri University
  • Ersin Turan Sağlık Bilimleri University
  • Meryem İlkay Eren Karanis Sağlık Bilimleri University
  • Umut Ulusoy Sağlık Bilimleri University
  • Osman Doğru Sağlık Bilimleri University

Abstract

Objective: Peripheral blood derived inflammation based scores are proposed as prognostic markers in solid tumors especially in gastrointestinal system. We aimed to investigate the association between neutrophyl/lymphocyte ratio (NLR, platelet/lymphocyte ratio (PLR) and breast cancer in means of prognostic forecast.

Methods: Of 190 patients diagnosed and operated for breast cancer. 160 patients with available pretreatment blood count were included. Ultrasound, mammography, and pathology results were also recorded.

Results: The median age was 50 years at the time of diagnosis (28-90 years). Family history was positive in 11 patients. There were 139 patients with invasive ductal carcinoma, 15 patients with invasive lobuler carcinoma. There was no association with histopathological type of the tumor and peripheral blood derived inflammation markers. The difference in PLR between T1 and T4 tumors was statistically significant. Also both NLR and PLR were significant when N0 patients compared with N1 patients (p<0.05). Neither estrogen nor progesterone receptor status was shown to have an association with NLR and PLR. PLR was found to be statistically significant in different pathological grade groups.

Conclusion: Both NLR and PLR were found to be correlated with advanced stage breast cancer so with prognosis. In order to use these markers in clinical practice, more clinical trials with large number of patients and long follow up period are needed. 

Author Biographies

Hande Köksal, Sağlık Bilimleri University,

Konya Education and Research Hospital, Department of General Surgery

Emet Ebru Nazik, Sağlık Bilimleri University

Konya Education and Research Hospital, Department of General Surgery

Ersin Turan, Sağlık Bilimleri University

Konya Education and Research Hospital, Department of General Surgery

Meryem İlkay Eren Karanis, Sağlık Bilimleri University

Konya Education and Research Hospital, Department of Pathology

Umut Ulusoy, Sağlık Bilimleri University

Konya Education and Research Hospital, Department of General Surgery

Osman Doğru, Sağlık Bilimleri University

Konya Education and Research Hospital, Department of General Surgery

References

Hanahan D. Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011; 144: 646-74.

DeNardo DG. Coussens LM. Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res. 2007; 9: 212.

Li MX. Liu XM. Zhang XF. et al. Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: a systematic review and meta-analysis. Int J Cancer. 2014; 134: 2403-13.

Azab B. Bhatt VR. Phookan J. et al. Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients. Ann Surg Oncol. 2012; 19: 217-24.

Guthrie GJ. Charles KA. Roxburgh CS. et al. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol. 2013; 88: 218-30.

Hanahan D. Weinberg RA. The hallmarks of cancer. Cell. 2000; 100: 57-70.

Balta S. Demirkol S. Kucuk U. Sarlak H. Kurt O. Arslan Z. Neutrophil to lymphocyte ratio may predict mortality in breast cancer patients. J Breast Cancer. 2013; 16: 354-5.

Templeton AJ. McNamara MG. Šeruga B. et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst. 2014; 106: dju124.

Cihan YB. Arslan A. Cetindag MF. Mutlu H. Lack of prognostic value of blood parameters in patients receiving adjuvant radiotherapy for breast cancer. Asian Pac J Cancer Prev. 2014;15: 4225-31.

Noh H. Eomm M. Han A. Usefulness of pretreatment neutrophil to lymphocyte ratio in predicting disease-specific survival in breast cancer patients. J Breast Cancer. 2013; 16: 55-9.

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Published

26.12.2016

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Section

Original Research

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