The Association of MCP-1 Level and MCP-1 -2518 A/G and CCR2 190 G/A Gene Polymorphisms with COPD and Pulmonary Hypertension


  • Malik Ejder Yıldırım Cumhuriyet University,
  • Serdar Berk Cumhuriyet University
  • Hande Küçük Kurtulgan Cumhuriyet University
  • Gülaçan Tekin Cumhuriyet University
  • Yusuf Kenan Tekin Cumhuriyet University
  • Burak Başer Cumhuriyet University
  • Gökhan Bağcı Cumhuriyet University
  • Serpil Erşan Cumhuriyet University
  • Hasan Kılıçgün Erzincan Binali Yıldırım University


Objective: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by obstructed airflow in the lungs. Pulmonary hypertension (PH) is a common complication of COPD and it is associated with pulmonary vascular remodelling. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines associated with migration of monocytes and macrophages. Both MCP-1 and its receptor CCR2 have been declared to be involved in various diseases. We aimed to research a possible association of MCP-1 level, MCP-1 -2518 A/G and CCR2 190 A/G polymorphisms with COPD and pulmonary hypertension in this study.

Material and methods: Eighty patients and eighty controls were included in the study. Serum MCP-1 levels were measured by ELISA method. Restriction fragment length polymorphism (RFLP) procedure was used to detect the genotypes of patients and control group.

Results: MCP-1 levels were found to be significantly higher in COPD patients than in healthy controls (P=0.001) and patients with COPD + PH had higher serum MCP-1 levels than COPD patients (P=0.005). No association was found between MCP-1/CCR2 gene polymorphisms and patient groups (COPD and COPD + PH).

Conclusion: MCP-1 level seems to be associated with both COPD and pulmonary hypertension. Increased MCP-1 expression may most likely to be involved in the pathogenesis of these diseases.

Author Biographies

Malik Ejder Yıldırım, Cumhuriyet University,

Cumhuriyet University, Faculty of Medicine, Department of Medical Genetics, Sivas.

Serdar Berk, Cumhuriyet University

Cumhuriyet University, Faculty of Medicine, Department of Chest Disease, Sivas.

Hande Küçük Kurtulgan, Cumhuriyet University

Cumhuriyet University, Faculty of Medicine, Department of Medical Genetics, Sivas.

Gülaçan Tekin, Cumhuriyet University

Cumhuriyet University, Faculty of Medicine, Department of Cardiology, Sivas

Yusuf Kenan Tekin, Cumhuriyet University

Cumhuriyet University, Faculty of Medicine, Department of Emergency Medicine, Sivas.

Burak Başer, Cumhuriyet University

Cumhuriyet University, Faculty of Medicine, Department of Medical Genetics, Sivas.

Gökhan Bağcı, Cumhuriyet University

Cumhuriyet University, Faculty of Medicine, Department of Medical Genetics, Sivas.

Serpil Erşan, Cumhuriyet University

Cumhuriyet University, Faculty of Medicine, Department of Biochemistry, Sivas

Hasan Kılıçgün, Erzincan Binali Yıldırım University

Erzincan Binali Yıldırım University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Erzincan. Turkey


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Original Research