The Predictive Value of Inflammatory Markers in the First Year of Diagnosis in Ulcerative Colitis
AbstractObjective: The aim of this study was to determine if the changes in inflammatory markers which were observed during the routine follow-up of patients with ulcerative colitis could predict the disease progression. Methods: Levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), hemoglobin (Hb), white blood cell count (WBC), neutrophil-lymphocyte ratio (NLR), mean platelet volume (MPV) and albumin (alb), which were observed at the time of diagnosis as well as in the 3rd, 6th, 9th and 12th months, were recorded retrospectively. The area under the curve (AUC) of the variation of these values with respect to time was calculated. Results: 118 patients were subjects of this study, with a mean follow-up time of 3.4 years. The calculated AUCs for CRP, ESR, WBC, and NLO were significantly higher ( p<0.001,p<0.01,p<0.01,p<0.01 ); whereas the ones for Hb, alb, and MPV were significantly lower (p<0.01,p<0.001,p<0.05) in patients who used an immunomodulator compared to those who did not. The calculated AUCs for CRP and ESR were significantly higher (p<0.001,p<0.05); whereas the AUCs for Hb, alb, and MPV were significantly lower (p<0.01,p<0.05,p<0.01) in patients who used an anti-tumor necrosing factor-alpha inhibitor (anti-TNF) compared to those who did not. Additionally, in patients who used anti-TNF, the AUCs for CRP were significantly higher ( ), than in patients who only used immunomodulators. Conclusion: The levels of inflammatory markers in the early course of the disease are helpful for predicting the disease progression and prognosis. We assume that, the higher the CRP, the worse the prognosis.
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