The Effects of Taurine, Melatonin and N-Acetylcystein on Cadmium Exposure Bone Changes “The Surprising Effect of Taurine”

  • Nurettin Tastekin Trakya University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Edirne
  • Nurettin Aydogdu Trakya University, Faculty of Medicine, Department of Physiology, Edirne
  • Gulay Altun Durmus Trakya University, Faculty of Medicine, Department of Nucleer Medicine, Edirne
  • Hakan Erbas Trakya University, Faculty of Medicine, Department of Biochemistry, Edirne
  • Kaan Uzunca Trakya University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Edirne
  • Murat Birtane Trakya University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Edirne
  • Mustafa Kaplan Trakya University, Faculty of Medicine, Department of Urology, Edirne
  • Murat Erem Trakya University, Faculty of Medicine, Department of Orthopaedic Surgery and Traumatology, Edirne

Abstract

Background: Chronic environmental and occupational exposure to cadmium can result in skeletal system changes. The main objective of the present study was to investigate and compare the effects of taurine, melatonin and N-acetyl cysteine on cadmium exposure induced bone density loss. Methods: 90 adult male Sprague-Dawley rats were allocated into four main groups: Group I was the control group; Group II was the “cadmium exposure” group; Group 3 was “cadmium exposure for 3 months + concurrent antioxidant administration” group. The concept of Group 4 was cadmium exposure for 3 months + subsequent antioxidant administration. Bone mineral density values were evaluated in all the groups. Serum calcium, phosphorus, alkaline phosphatase (ALP) enzyme activities and 24 hours urine calcium excretion levels were measured. Kruskal–Wallis test was used to compare the all groups. Between two group comparisons, the Mann–Whitney U test was used. Results: There was no significant difference in terms of bone mineral density values only between control group and cadmium exposure group (p>0.05). Mean bone mineral density values obtained in “cadmium + concurrent taurine” and “cadmium + subsequent taurine” groups were significantly lower than all the other groups (p<0.05). 24 hours urine calcium excretion levels were significantly higher in groups which taurine and n-asetylcystein were administered after cadmium exposure. Conclusion: Taurine, which is thought to have protective effects as an antioxidant caused a marked bone damage after exposure to cadmium. Further studies are needed to clarify this effect of taurine.

Author Biographies

Nurettin Tastekin, Trakya University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Edirne
MD, Prof
Nurettin Aydogdu, Trakya University, Faculty of Medicine, Department of Physiology, Edirne
MD, Prof
Gulay Altun Durmus, Trakya University, Faculty of Medicine, Department of Nucleer Medicine, Edirne
MD, Prof
Hakan Erbas, Trakya University, Faculty of Medicine, Department of Biochemistry, Edirne
MD, Prof
Kaan Uzunca, Trakya University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Edirne
MD, Prof
Murat Birtane, Trakya University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Edirne
MD, Prof
Mustafa Kaplan, Trakya University, Faculty of Medicine, Department of Urology, Edirne
MD, Assoc, Prof
Murat Erem, Trakya University, Faculty of Medicine, Department of Orthopaedic Surgery and Traumatology, Edirne
MD

References

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Published
2020-09-12
Section
Original Research