The Prophylactic and Protective Effects of Terfezia Claveryi Extracts on Ibuprofen Induced Oxidative Stress in Pregnant Rats

  • Mohammed Talat Abbas Department of Pharmaceutical Chemistry, College of Pharmacy, kerbala university , kerbala-Iraq
Keywords: Ibuprofen, Terfezia Claveryi, Oxidative stress, Pregnant rats

Abstract

Objective: This study aimed to investigate the prophylactic and protective roles of Terfezia Claveryi extracts on Ibuprofen induced oxidative stress in pregnant albino rats. Methods: Thirty pregnant rats randomly divided in to five experimental groups, each group consist of six pregnant rats. Group 1 (control group): without any treatment. Group 2 (Ibuprofen group): Given Ibuprofen orally by gastric tube at dose of 40 mg/kg/day for 20 days. Group 3 (Terfezia Claveryi group): Received Terfezia Claveryi extracts via gavage at 250 mg/kg every day dose. Group 4 (Ibuprofen +Terfezia Claveryi group): Received with Ibuprofen at dose of 40 mg/kg every day plus Terfezia Claveryi extracts 250 mg/kg /day by gastric tube along the experiment. Group 5 (Terfezia Claveryi + Ibuprofen): Received with 250 mg/kg every day of Terfezia Claveryi via gavage for two weeks before gestation (as a prophylactic) and then treated with Ibuprofen at the above-mentioned dose at zero day of gestation to twenty day of the experiment. Results: Ibuprofen increased serum AST, ALT, ALP activity, total bilirubin concentration, Liver tissue MDA levels and decreased liver tissue Catalase, Superoxide Dismutase and Glutathione Peroxidase. However, this modulation of the biological parameter is significantly ameliorated by the administration of the Terfezia Claveryi. Conclusion:In conclusion prophylactic and protective effect of Terfezia Claveryi against Ibuprofen induced oxidative stress was reported in pregnant rats.

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Published
2019-06-21
Section
Original Research