The Impacts of Central Fatigue on the Polyphasic Nature of Tapping Performance

  • Leyla Aydın Baskent Unv., Fac. of Medicine, Dept. of Physiology, Ankara, Turkey
  • Erhan Kızıltan
  • Ersin Öğüş
  • Bahadır Azizağaoğlu
  • Arda Büyükkaraman
  • Selen Doğan
  • Gizem Ertürk
  • Cansel Kuş
Keywords: Central fatigue, peripheral fatigue, fatigue model, repetitive movements, tapping performance, temporal behavior


Objective: As a non-specific symptom muscle fatigue mostly accompanies neuromuscular diseases and also occurs frequently in healthy individuals. Fatigue phenomenon is considered to be multidimensional symptom. There have been still discussions on the origin whether it depends primarily on the intrinsic properties of muscle itself (peripheral mechanisms) or the nervous system that controls muscle (central mechanisms). This study aimed to investigate the effects of central fatigue on the performance of maximal voluntary repetitive movement and discusses the specificity of finger tapping task test as a simple diagnostic tool for fatigue. Methods: For this purpose, 27 healthy, male, right-handed volunteer performed the 20-s of finger tapping task test for four times. The one was for control and the other three were performed right after induction of three different central fatigue models. Temporal behavior of tapping performances were evaluated based on inter-tap intervals and the statistical comparison were made by regression analysis. Results: The results showed that the partial evaluation of the task in time domain instead of complete test period yielded with statistically significant differences between control and fatigue models (p<0.001) and even in between the fatigue models. Conclusion: Approximately the first 5-s of a finger tapping task consists of both motor learning processes and dynamics of energy consumption from anaerobic sources. However, it reflects dominantly the central components of fatigue. We may conclude that the temporal behavior of tapping performance following the induction of specific fatigue model may help making further discrimination for the origin of fatigue.


Wurster C.D, Graf H, Ackermann H, Groth K, Kassubek J, Riecker A.Neural correlates of rate-dependent finger-tapping in Parkinson’s disease. Brain Struct Funct. 2015; 220: 1637–48.

Morgante F, Dattola V, Crupi D, Russo M, Rizzo V, Ghilardi M.F, Terranova C, Girlanda P. Quartarone A. Is central fatigue in multiple sclerosis a disorder of movement preparation? J Neurol. 2011; 258: 263–72.

Angelini C and Tasca E. Fatigue in muscular dystrophies. Neuromuscular Disorders 2012;22: S214–20.

Berger A.M, Gerber L.H, Mayer D.K.Cancer-Related Fatigue. Cancer. 2012; 118(8 suppl): 2261-9.

Leavitt V.M, DeLuca J. Central fatigue: issues related to cognition, mood and behavior, and psychiatric diagnoses. PM R. 2010; 2: 332-7.

Gandevia S.C. Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 2001; 81:1725–89.

Ghosh VE., Gilboa A. What is a memory schema? A historical perspective on current neuroscience literatüre. Neuropsychologia. 2014:53;104–14.

Ranieri F, Di Lazzaro V. The role of motor neuron drive in muscle fatigue. Neuromuscular Disorders. Neuromuscul Disord. 2012; 22(Suppl 3): S157-61.

Chakravarthy VS, Joseph D, Bapi RS. What do the basal ganglia do? A modeling perspective. Biol Cybern. 2010;103:237-53.

Chaudhuri A and Behan P.O. Fatigue and basal ganglia. Journal of the Neurological Sciences. 2000;179: 34–42.

Taylor J.L, Allen G.M, Butler J.E, Gandevia S.C. Supraspinal Fatigue During İntermittent Maximal Voluntary Contractions of The Human Elbow Flexors. J Appl Physiol. 2000; 89: 305–13.

Arias P, Robles-Garcia V, Corral-Bergantinos Y, Madrid A, Espinosa N, Valls-Sole J, Grieve K.L, Oliviero A, Cudeiro J. Central Fatigue Induced by Short-Lasting Finger Tapping and Isometric Tasks: A Study of Silent Periods Evoked at Spinal and Supraspinal Levels. Neuroscience. 2015; 305; 316–27.

Bishop D.J. Fatigue during intermittent−sprint exercise. Clin Exp Pharmacol Physiol. 2012; 39: 836–41.

Berchicci M, Menotti F, Macaluso A, Di Russo F. The neurophysiology of central and peripheral fatigue during sub-maximal lower limb isometric contractions. Front Hum Neurosci. 2013; 7 (article 135): 1-10.

Barut, C, Kiziltan, E, Gelir, E, & Kokturk, F. Advanced analysis of finger-tapping performance: A preliminary study. Balkan Medical Journal, 2013; 30: 167–71.

Aydin L, Kiziltan E, Gundogan N.U. Polyphasic Temporal Behavior of Finger-Tapping Performance: A Measure of Motor Skills and Fatigue. Journal of Motor Behavior. 2016; 48: 72-8.

Kızıltan E, Aydın L. Internal motivation modulates voluntary repetitive movements: “Ha gayret” energy. Acta Physiologica, 2017; 221(S714):81-81.

Andrieux M, Boutin A, Thon B. Self-Control of Task Difficulty During Early Practice Promotes Motor Skill Learning, Journal of Motor Behavior. 2016: 48: 1, 57-65.

Wells GD, Selvadurai H, Tein I. Bioenergetic provision of energy for muscular activity. Paediatric Respiratory Reviews. 2009; 10, 83–90.

Bilodeau M. Central Fatigue in Continuous and Intermittent Contractions of Triceps Brachii. Muscle Nerve. 2006; 34: 205–13.

Tan U. The distribution of hand preference in normal men and women. Int. J. Neurosci. 1988;41:35-55.

Hotermans C, Peigneux P, Maertens de Noordhout A, Moonen G, Maquet P. Early boost and slow consolidation in motor skill learning. Learn Mem. 2006; 13: 580-3.

Tan H, Pogosyan A, Ashkan K, Cheeran B, FitzGerald J.J, Green A, Aziz T, Foltynie T, Limousin P, Zrinzo L, Brown P. Subthalamic nucleus local field potential activity helps encode motor effort rather than force in parkinsonism. J Neurosci. 2015;35:5941-9.

Kiziltan E, Barut C, Gelir E. A high-precision, low cost system for evaluating finger-tapping tasks. Int J Neurosci 2006; 116: 1471-80.

Hornbeck, R. W. Least squares curve fitting and functional approximation. In R. W. Hornbeck (Ed.), Numerical methods 1975; (pp. 121–129). New York, NY: Quantum.

Loiselle D.S, Walmsley B. Cost Of Force Development As A Function Of Stimulus Rate In Rat Soleus Muscle. Am J Physiol. 1982; 243: C242-6.

Schmidt, R.A. A schema theory of discrete motor skill learning. Psychological review. 1975; 82: 225-60.

Original Research