Protective Effects of Resveratrol in a Rat Model of Ischemia-Reperfusion Injury of Sciatic Nerve

  • Onur Akarca
  • Özgür Öcal
  • Erkut Baha Bulduk department of neurosurgery
  • Özge Tuğçe Paşaoğlu
  • Ayşe Çakır Gündoğdu
  • Gülnur Take Kaplanoğlu
  • Aydın Paşaoğlu
Keywords: Sciatic nerve, ischemia- reperfusion injury, resveratrol, rat, nitric oxide, malondialdehyde


Objective: The aim of this study was to determine the effects of resveratrol on ischemia- reperfusion (I/R) injury in the rats sciatic nerve. Methods: We used 18 Wistar rats anesthetized with ketamine (50 mg/kg-im). In the sham group, we only performed the surgery and not administer any medication. In the ischemia group, we generated I/R injury in 5 minute intervals with medical treatment of saline only. In the resveratrol group, we brought about the same I/R injury but gave resveratrol before the surgery by per oral. After sacrifice, we studied blood and nerve tissue samples. We evaluated the damage with malondialdehyde (MDA), nitric oxide (NO), and total antioxidant capacity (TAC), both in tissue and blood. Results: Evaluation of serum levels of antioxidant markers and tissue samples demonstrated statistically significant effects of resveratrol in ischemia-reperfusion injury. Conclusion: This study revealed the antioxidant effect of resveratrol as an inhibitor of lipid peroxidation.


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Original Research