The THE EVALUATION OF PERIPAPILLARY RETINAL NERVE FIBER LAYER THICKNESS CHANGES IN RETINITIS PIGMENTOSA AND EARLY- LATE STAGE GLAUCOMA Glaucoma and Retinitis Pigmentosa

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Kürşad Ramazan Zor
Erkut Küçük
Gamze Yıldırım
Ulviye Kıvrak

Abstract

Abstract:
Objective:  The aim of the study is to evaluate the peripapillary retinal nerve fiber layer (RNFL) thickness of patients with retinitis pigmentosa (RP) and  patients with early- and late-stage glaucoma using spectral domain optical coherence tomography (sd-OCT), and investigate the similarity and differences of RNFL thickening and thinning regions between these groups. 


Methods: This cross-sectional study was carried out in Niğde Ömer Halisdemir University Training and Research Hospital. The patients were divided into three groups; retinitis pigmentosa (group 1), early-stage glaucoma (group 2), and medium- and advanced-stage glaucoma (group 3). The RNFL thickness of all patients were measured. Each group consisted of 20 patients.


Results: RNFL thinning was most frequently detected in the inferior quadrant, and then in the superior quadrant in all 3 groups and thickening was not detected in these 2 quadrants in glaucoma groups. The thickening was most frequently detected in the temporal quadrant, and in the 9 o’ clock segment in all groups. In groups 1 and 2, the nasal quadrant was second after the temporal quadrant in RNFL thickening. RNFL thickening and thinning regions were found to be similar in these 2 diseases, which progress with ganglion cell damage. The horizontal quadrants were less affected and vertical quadrants were more affected regardless of the disease. 
 
Conclusion: The similar changes in the RNFL layer in these 2 different diseases with different mechanisms suggest that ganglion cells might have a specific response to various disease processes. 

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Original Research