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Endoscopic retrograde cholangiopancreatography (ERCP) is widely used in the diagnosis and treatment of pancreatobiliary diseases. The most serious complication that develops post ERCP is perforation of gastrointestinal tract and it can be mortal. ERCP-related pneumothorax is a rare complication requiring urgent intervention. We present a case of 50- year-old female patient who developed bilateral pneumothorax after ERCP. Keywords: Bilateral Pneumothorax, ERCP, duodenum perforation.