The Effects of 2600 MHz Radiofrequency Radiation and Melatonin on Skin and Liver Tissue Hydroxyprolin Levels of Male Rats

Effects of melatonin on radiofrequency radiation


  • Sinem Oruç gazi üniversitesi
  • Kevser DELEN Gazi Üniversitesi
  • Armağan YARDIM
  • Bahriye SIRAV ARAL
  • Dilek KUZAY
  • Cemile Merve SEYMEN



Objective: In the present study, the effect of 2600 MHz radiofrequency radiation (RFR) exposure, and melatonin treatment on skin and liver tissue hydroxyproline levels was evaluated.

Methods: In the study, 2600 MHz RFR application was performed by Rohde & Schwartz Radiofrequency signal generator via ETS-Lindgren horn antenna. 36 wistar albino male rats were randomly divided into 6 groups (n = 6); Control, sham, RFR, control + Melatonin, Sham + Melatonin, RFR + Melatonin. RFR was applied to the related groups for 30 days (5 days / week) for 30 minutes a day. The RFR level was measured as ± 21.74 V / m. Melatonin groups were subcutaneously injected with melatonin (10 mg / kg) for 30 days. At the end of the experiment, hydroxyproline levels were measured in the skin and liver tissues.

Results: Hydroxyproline levels in skin tissue decreased significantly in RFR treated groups compared to the control and sham groups (p <0.05). Also, Hyp levels in skin tissue decreased significantly in RFR + melatonin treated group compared to the control, sham and sham+melatonin groups. No changes in hydroxyproline levels in liver tissue were determined.

Conclusion: In this study, RFR exposure lead to significant changes in skin Hyp levels but not liver tissue. This effect is thought to be due to the closer the skin tissue to the surface.






Original Research