A rare t(11;17) in Secondary Acute Myeloid Leukaemia following treatment of Hodgkin Lymphoma; A case report and literature review

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Secondary Acute Myeloid Leukaemia (AML) is referred to as Therapy-related Acute Myeloid Leukaemia (t-AML) or AML evolving from antecedent haematological disorders and it is a rare disease. We report a case of 40-year-old ladywho developed AML after four years on multiple lines of treatment due to Refractory Hodgkin Lymphoma. She presented with progressive lethargy and pancytopenia. Bone marrow aspiration, trephine biopsy and flow cytometry immunophenotyping findings suggest Acute Myelomonocytic Leukaemia (AMML). Cytogenetic analysis showed the presence of rare t(11;17). This translocation was predominantly in AMML and Acute Monoblastic/Monocytic Leukaemia  or variant type of acute promyelocytic leukemia (M3) and rarely associated with therapy-related AML.

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Case Report