KIDNEY STONE IN CHILDREN: DOES HYPOSITRATURE UNDERDIAGNOSED?

NEPHROLİTİASİS İN CHİLDREN

Authors

  • Songül Yılmaz Yıldırım Beyazıt Üniversitesi Yenimahalle Eğitim ve Araştırma Hastanesi
  • SARE GÜLFEM ÖZLÜ Ankara Yıldırım Beyazıt Üniversitesi, Yenimahalle Eğitim ve Araştırma Hastanesi, Çocuk Sağlığı ve Hastalıkları ABD https://orcid.org/0000-0002-9609-1511

Abstract

KIDNEY STONE IN CHILDREN: DOES HYPOSITRATURE UNDERDIAGNOSED?

Abstract

Objective: The frequency of kidney stones is gradually increasing and it is endemic in our country. The aim of our study is to evaluate the clinical, laboratory, radiological and follow-up findings of children with kidney stones and to investigate the etiology and factors affecting prognosis.

Methods: The files of 209 children who were followed up in the pediatric nephrology outpatient clinic for kidney stones were analyzed retrospectively. Demographic data, laboratory and radiological findings, and follow-up data of the patients were recorded. The patients were grouped by age and the groups were compared in terms of demographic characteristics and underlying metabolic abnormalities. Multivariate logistic regression analysis was used to determine the factors that may affect the resolution of the stone at the end of the follow-up.

Results: Of the 209 children included in the study, 107 were girls and 102 were boys. The median age was 18 months (1-214 months). Kidney stones were present in the family in 56% of the patients. It was noteworthy that approximately half of the patients were diagnosed at the first two years of age, and the most common symptom was restlessness. At least one metabolic abnormalities were detected in 52% of the patients, the most common metabolic disorders were hypocitraturia (34.3%) and hypercalciuria (27%). In follow-up, the frequency of stone disappearance was significantly higher in children with microlithiasis (71% and 46% p <0.001). When the age, gender, family stone history, stone size, number and underlying metabolic abnormality of the factors that may affect stone disappearance in the follow-up were evaluated with multiple logistic regression analysis; only small stone size was found to affect prognosis (p: 0.009, odds ratio: 2.39, 95% confidence interval 1.2- 4.6).

Conclusion: Kidney stones may present with nonspecific symptoms in childhood, so care should be taken in terms of stone in such patients with a family history of stones. The most common cause of stone is hypocitraturia and hypercalciuria, especially hypocraturia is thought to be underdiagnose in clinical practice. The most important factor in resolution od stones during follow-up has been shown to be the size of the stone.

Keywords: Kidney stones, nephrolithiasis, hypocitraturia, hypercalciuria, child.

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Published

2021-04-05

How to Cite

Yılmaz, S., & ÖZLÜ, S. G. (2021). KIDNEY STONE IN CHILDREN: DOES HYPOSITRATURE UNDERDIAGNOSED? NEPHROLİTİASİS İN CHİLDREN. Gazi Medical Journal, 32(2). Retrieved from http://medicaljournal.gazi.edu.tr/index.php/GMJ/article/view/2348

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Original Research