dddd The Effect of Ursodeoxycholic Acid Treatment on Pruritus and Alanine Amino Transferase Levels in Intrahepatic Cholestasis of Pregnancy
Intrahepatic Cholestasis of Pregnancy and Ursodeoxycholic Acid
Objective: Intrahepatic cholestasis of pregnancy is a pregnancy complication characterized by pruritus, elevation in liver enzymes and concentration of serum bile acids. In the current study, we aimed to investigate the relationship between pruritus and the level of alanine aminotransferase (ALT) and serum bile acids.
Methods: Thirty pregnant women with diagnosed of intrahepatic cholestasis of pregnancy at the gastroenterology outpatient clinic of XXX in 2008 were enrolled in the study. Data including patient age, pregnancy week, delivery week, pruritus score, level of serum bile acids and ALT levels were recorded.
Results: The mean age of pregnant women was 29.9±6.5 and the mean week of pregnancy was 31.8±3,74. There was no statistically difference of ALT serum level (45±35 U/L) after UDCA treatment (p=0.87). The mean serum level of ALT after delivery in pregnant women was 22±5 U/L and a statistically significant difference between serum ALT level after UDCA treatment was found (p=0.002). Before and after treatment, VAS scores were determined as 6,6±1,44 and 2,03±1,49 respectively. A significant difference was found between VAS scores after UDCA treatment (p=0.02).
Conclusion: The treatment of UDCA in intrahepatic cholestasis of pregnancy positively effects on level of pruritus, but does not contribute to regression of ALT level.
Key words: Intrahepatic cholestasis of pregnancy, Pruritus, Serum bile acid level, Alanine Amino Transferase.