Rewarding Conversation Between Oocyte and Cumulus Cells Directs the Process of Folliculogenesis

  • Duygu Dayanır Gazi University School of Medicine
  • Halil Ruso Gürgan Clinic Women's Health- Infertility and IVF Center
  • Ziya Kalem Gürgan Clinic Women's Health- Infertility and IVF Center
  • Timur Gürgan Gürgan Clinic Women's Health- Infertility and IVF Center
  • Candan Özoğul University of Kyrenia Faculty of Medicine


The process of folliculogenesis needs a balanced environment to create a mature oocyte that is expected to have characteristics in order to form the ability of a healthy fertilisation. Previous studies have been focused on endocrine effects of hypothalamic–pituitary system on ovarian functions. Influences of this system have been studied for many years. Besides of extra-ovarian factors, recent studies have focused on intraovarian factors which forms the relationship between oocyte and cumulus cells. It has been shown that even the maturity of antral follicule and oocyte has been effected from this communication. These factors which takes part at process of folliculogenesis, were shown to be efficient even at the success of assisted reproductive technologies. We studied general lines of this conversation based on main research articles that continue to be relevant at this topic.

Author Biographies

Duygu Dayanır, Gazi University School of Medicine
Histology and Embryology Department, MD
Halil Ruso, Gürgan Clinic Women's Health- Infertility and IVF Center
IVF Laboratory, MSC
Ziya Kalem, Gürgan Clinic Women's Health- Infertility and IVF Center
Gynecology Department, MD
Timur Gürgan, Gürgan Clinic Women's Health- Infertility and IVF Center
Gynecology Department, Prof MD
Candan Özoğul, University of Kyrenia Faculty of Medicine
Histology and Embryology Department, Prof PhD


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