A Rare Reason in Acute Hepatitis: Brucella

  • Ayşegül Bükülmez Afyonkarahisar Health Science University Faculty of Medicine
  • Pelin Balıkoğlu
  • Ayşe Tolunay Oflu


Brucellosis is a zoonosis caused by the genus Brucella. It is the most common zoonosis especially in underdeveloped and developing countries. Brucellosis is a systemic disease may involve multisystem or any organs. Clinical manifestations and symptoms have variable characteristics. For this reason, it is known as a ‘great imitator’ in the medical literature. Reticuloendothelial system involvement is one of the most important features of brucella infection. The liver is the largest organ of the reticuloendothelial system. Therefore, the most frequently affected organ is the liver. The patients may have mild elevation of transaminases. Acute hepatitis is a rare manifestation of brucellosis. Two sisters diagnosed with acute hepatitis due to brucellosis are presented in this case report. The aim of the case report is to emphasize the importance that brucellosis is kept in mind for the differential diagnosis of acute hepatitis in regions where the brucellosis is endemic.

Author Biography

Ayşegül Bükülmez, Afyonkarahisar Health Science University Faculty of Medicine
Department of Pediatrics


Young JE. Brucellosis In J Cherry, GJ. Demmler-Harrison, SL. Kaplan, WJ Steinbach, PJ Hotez editors Feigin and Cherry's Textbook of Pediatric Infectious Diseases 8th edition. E-Book, Kindle Edition, 1156-1159

Talwani R,.Gilliam BL, Howell C. Clin Liver Dis 15; 2011: 111–130

Van Winkle-Preston L, Drew ML. Pediatric brucellosis: a case study. J Pediatr Health Care. 2014 Mar-Apr;28(2):177-81.

Ulug M, Celen MK, Ayaz C. Braz J İnfect Disease 2010;14(6):641-642

Aykın N, Naz H, Çevik F. Brucellozise bağlı akut hepatit: olgu sunumu Dicle Tıp dergisi 2009;36:2, 134-136

Arıca V, Arıca SG, Şilfeler İ, Onur H, Tanır M. Atipik prezentazyonlu brucellozis olgusu: akut hepatit J kartal TR 2010; XXI(1): 45-48

Parlak M, Akbayram S, Doğan M ve ark. Clinical manifeatations and laboratory findings of children with brucellosis in Van, Turkey. Pediatr Int 2015; 57(4) 586-589