Lymphoma of the Alveolus: A Rare Entity

  • Jeyasakthy Saniasiaya Department ORL-HNS, Universiti Sains Malaysia
  • Irfan Mohamad
  • Mohan Kameswaran
  • Murali Susruthan
Keywords: Lymphoma, Non-Hodgkin, B-cell lymphoma, hard palate


Extranodal lymphoma of the oral cavity accounts for 3.5% of all oral cavity malignancies. Its rarity poses a challenge to clinicians in diagnosing this entity in the clinical setting. Common sites of extranodal lymphoma are in the gastrointestinal tract. In the oral cavity, palatine tonsils predominates the site of origin as the histology of the Weldeyer’s ring structure is composed mainly of lymphoid follicles. Herein, we are reporting a case of an elderly gentleman who presented with a history of loosening of teeth followed by painless swelling over the hard palate which turned out to be non-Hodgkin’s lymphoma. Histopathological with further immunohistochemistry study revealed a B-cell type of non-Hodgkin’s lymphoma. Albeit rare, extranodal non-Hodgkin’s lymphoma ought to be considered as a differential diagnosis for oral cavity tumour especially with a palatal swelling post-tooth extraction.


Jayakrishnan R, Thomas G, Kumar A, Nair R. Non-Hodgkin's lymphoma of the hard palate. J Oral Maxillofac Pathol. 2008;12:85–7.

Metser U, Goor O, Lerman H, Naparstek E, Even-Sapir E. PET-CT of extranodal lymphoma. AJR Am J Roentgenol. 2004;182:1579-86.

The CS, Chong SY. An unusual presentation of lymphoma of the head and neck region. Med J Malaysia. 2011;66:264-5.

Lin HC, Chang TA, Lin KL. Non-Hodgkin’s lymphoma presented as a tongue base tumour: A case report. Changhua J Med. 2003;8:190-3.

Isaacson PG, Wright DH. Malignant lymphoma of the mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma. Cancer. 1983;52:1410-2.

Kemp S, Gallagher G, Kabani S, Noonan V, Hara C. Oral non-Hodgkin’s lymphoma: review of the literature and World Health Organization classification with reference to 40 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:194-1.

Gedik R, Gedik S, Goze F, Develioglu H. Lymphoma in the infraorbital region. IADA. 2003;134:1353-5.

Pandit V, Jain I, Gaur R. Diffuse B-cell Non Hodgkins Lymphoma of Palate-A case report. IJAR. 2016;6:340-2.

Saharan D, Gupta AK, Kapoor A, Kapoor AR. Primary non-Hodgkin;s lymphoma arising from the soft palate: A diagnostic dilemma. IJPSR. 2016;7:6-8.

Gaweda A, Jach E, Wojciechowicz J, Sokolowska B, Tomaszewski T. Diffuse large B cell lymphoma of the oral cavity-Case report. J Pre-Clin Clin Res. 2014;8:27-9.

Adkins KF. Lymphoid hyperplasia in the oral mucosa. Aust Dent J. 1973;18:38-40.