Intranasal Extramedullary Plasmacytoma: A Rare Entity
AbstractExtramedullary or extraosseous plasmacytoma (EMP) is a rare neoplasm characterized by monoclonal proliferation of plasma cells arising outside the bone marrow. It shows a predilection for the head and neck region, primarily in the upper respiratory tract. The commonest site of occurrence are nasal cavities and nasal septum followed by oropharynx. Eventhough EMP of the nasal cavity is rare but it should be considered in the differential diagnosis of nasal cavity mass. This tumour may invade into the adjacent tissues and acts as a locally aggressive neoplasms. Thus, crucial attention to the clinical, radiological, and histopathological findings should be taken into consideration for accurate diagnosis. Furthermore, appropriate management must be carried out to prevent further dissemination of the disease. We report a case of a 54-year-old male who presented with a progressive nasal blockade for one-year duration, in which the biopsy of the left nasal cavity mass revealed EMP. He underwent endoscopic debulking surgery and then was subjected for radiotherapy. The clinical and histopathologic findings of plasmacytoma are discussed further.
Swerdlow SH. WHO classification of tumours of haematopoietic and lymphoid tissues. WHO Classification of Tumours. 2008;22008:439.
Bachar G, Goldstein D, Brown D, Tsang R, Lockwood G, Perez‐Ordonez B, et al. Solitary extramedullary plasmacytoma of the head and neck-Long‐term outcome analysis of 68 cases. Head & Neck. 2008;30(8):1012-9.
Soutar R, Lucraft H, Jackson G, Reece A, Bird J, Low E, et al. Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma. British Journal of Haematology. 2004;124(6):717-26.
Dores GM, Landgren O, McGlynn KA, Curtis RE, Linet MS, Devesa SS. Plasmacytoma of bone, extramedullary plasmacytoma, and multiple myeloma: incidence and survival in the United States, 1992–2004. British Journal of Haematology. 2009;144(1):86-94.
Group IMW. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. British Journal of Haematology. 2003;121(5):749-57.
Fu YS, Perzin KH. Nonepithelial tumors of the nasal cavity, paranasal sinuses and nasopharynx. A clinicopathologic study. IX. Plasmacytomas. Cancer. 1978;42(5):2399-406.
Booth J, Cheesman A, Vincenti N. Extramedullary plasmacytomata of the upper respiratory tract. Annals of Otology, Rhinology & Laryngology. 1973;82(5):709-15.
Wiltshaw E. The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine. 1976;55(3):217-38.
Zuo Z, Tang Y, Bi C-F, Zhang W-Y, Zhao S, Wang X-Q, et al. Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases. Diagnostic Pathology. 2011;6(1):123.
Creach KM, Foote RL, Neben-Wittich MA, Kyle RA. Radiotherapy for extramedullary plasmacytoma of the head and neck. International Journal of Radiation Oncology Biology Physics. 2009;73(3):789-94.
All opinions and reports within the articles that are published in the Gazi Medical Journal are the personal opinions of author(s). Gazi University, Editors and the publisher do not accept any responsibility for these articles. The journal is printed on acid-free paper.