The Effect of Mitomycin C on the number of Keratocytes on the Posterior Wall of the Stroma of Cornea after Photorefractive Keratectomy

  • Hanieh Ahmadi
  • Majid Reza Sheikh Rezaei
  • Mohammad Naeim AminiFard
  • Hamed Jafarpour


Introduction: We have decided to investigate its effect on a number of keratocytes on the posterior wall of the stroma of cornea, in which stromal removal depth has little effect on. Methods: This is a cohort clinical trial. All patients with the required criteria for entering the study after filling the consent, they were first examined by the Confoscan III system and then the number of keratocytes on the posterior wall of the stroma of cornea was measured. At the end of the treatment, patients were followed up (end of month 3) with posterior keratocytes cells’ count. Results: In this study, out of 13 patients (26 eyes) referring to the clinic, 8 (51.5%) were male and 5 (38.5%) were female. The mean refractive index before surgery was -3.6 ± 0.8 diopters. Also, the mean number of keratocytes on the posterior wall of the stroma of cornea after surgery was 714.7 ± 12.9, with the lowest of 697.5 and the highest of 726.3. There was no statistically significant difference between the number of keratocytes before and after surgery (P = 0.838). Conclusion: The use of 0.02% mitomycin, topically, during keratorefractive surgery does not affect the number of keratocytes on the posterior wall of the stroma of cornea.


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Original Research