Diclofenac sodium Induced Nicolau Syndrome

  • Engin Şenel Hitit University Faculty of Medicine, Department of Dermatology and Venereology, Çorum
  • Aynure Öztekin Hitit University Faculty of Medicine, Department of Dermatology and Venereology, Çorum
  • Ümran Muslu Hitit University Faculty of Medicine, Department of Plastic and Reconstructive Surgery, Çorum

Abstract

Nicolau syndrome (NS) also known as livedo-like dermatitis, is an uncommon but important cutaneous drug reaction. It was first described in 1924 and since then many patients have been reported in the literature. The disorder is characterized by intense pain in the injection site and followed by a livedoid reticular patch or indurated plaque. In some patients, this condition may progress into extensive necrosis of the skin and ulceration as seen in our patient. Herein we presented a 52-year-old man and presented with a painful, large ulcer on his left buttock after intramuscular diclofenac sodium administration and diagnosed with NS to draw attention of physicians to this rare and preventable condition.

References

Şenel E, Ada S, Güleç AT, Çaǧlar B (2008) Nicolau syndrome aggravated by cold application after i.m. diclofenac. J Dermatol. doi: 10.1111/j.1346-8138.2007.00404.x

Köhler LD, Schwedler S, Worret WI (1997) Embolia cutis medicamentosa. Int J Dermatol 36:197

Senel E (2012) Nicolau syndrome as an avoidable complication. doi: 10.4103/2230-8229.94017

Published
2020-09-12