The Immunohistochemical Expression of Matrix Metalloproteinases-2 and -9 in Low-Grade Appendiceal Mucinous Neoplasms: May These Neoplasms be Non-Invasive?

Authors

  • Özgür Ekinci Gazi University

Abstract

Objective: Low-grade appendiceal mucinous neoplasms (LAMN) are debated about their potential to cause invasion and pseudomyxoma peritoneii (PMxP). Our aim was to examine these neoplasms by two invasion markers: matrix metalloproteinases- 2 and -9 (MMP). Methods: Twenty-eight cases of mucinous adenomas, LAMNs and adenocarcinomas were included. Immunohistochemistry of MMP-2 and -9 were applied and scored. Results: Overall, the majority of LAMNs were negative by these two markers. Conclusion: LAMNs may not actually have an invasive nature but still they can cause PMxP. These patients should be followed.

Author Biography

Özgür Ekinci, Gazi University

Medical School Department of Medical Pathology

References

Bosman FT, Carnerio F, Hruban RH, Theise ND (Eds): WHO Classification of Tumours of the Digestive System. 4th ed. IARC: Lyon 2010.

Amin MB,‎ Edge SB,‎ Grene FL,‎ Byrd DR,‎ Brookland RK,‎ Washington MK,‎ Gershenwald JE,‎ Compton CC,‎ Hess KR,‎ Sullivan DC,‎ Jessup JM,‎ Brierley JD,‎ Gaspar LE,‎ Schilsky RL,‎ Balch CM,‎ Winchester DP,‎ Asare EA,‎ Madera M,‎ Gress DM,‎ Meyer LR. AJCC Cancer Staging Manual. 8th ed. Springer; 2017.

Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, et al. The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei. Histopathology 2017; 71: 847-58.

Westermarck J, Kähäri VM. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 1999; 13: 781-92.

Seiki M. Membrane-type 1 matrix metalloproteinase: a key enzyme for tumor invasion. Cancer Lett 2003; 194: 1-11.

Cockett MI, Birch ML, Murphy G, Hart IR, Docherty AJ. Metalloproteinase domain structure, cellular invasion and metastasis. Biochem Soc Trans 1994; 22: 55-7.

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Published

15.03.2018

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Section

Original Research