The Immunohistochemical Expression of Matrix Metalloproteinases-2 and -9 in Low-Grade Appendiceal Mucinous Neoplasms: May These Neoplasms be Non-Invasive?

  • Özgür Ekinci Gazi University
Keywords: Appendix, mucinous neoplasm, matrix metalloproteinase


Objective: Low-grade appendiceal mucinous neoplasms (LAMN) are debated about their potential to cause invasion and pseudomyxoma peritoneii (PMxP). Our aim was to examine these neoplasms by two invasion markers: matrix metalloproteinases- 2 and -9 (MMP). Methods: Twenty-eight cases of mucinous adenomas, LAMNs and adenocarcinomas were included. Immunohistochemistry of MMP-2 and -9 were applied and scored. Results: Overall, the majority of LAMNs were negative by these two markers. Conclusion: LAMNs may not actually have an invasive nature but still they can cause PMxP. These patients should be followed.

Author Biography

Özgür Ekinci, Gazi University
Medical School Department of Medical Pathology


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Original Research