Successful Treatment of Infective Endocarditis Vegetation with Recombinant Tissue Plasminogen Activator in a Term Newborn

  • Erbu Yarcı Zekai Tahir Burak Kadın Sağlığı Eğitim ve Araştırma Hastanesi, Yenidoğan Kliniği
  • Fatma Nur Sarı
  • Aslıhan Köse Çetinkaya
  • Handan Aslıhan Ünsal
  • Evrim Alyamaç Dizdar
  • Hayriye Gözde Kanmaz Kutman
  • Serife Suna Oguz
Keywords: Newborn, thrombocytopenia, infective endocarditis, S. aureus, vegetation, thrombolytic treatment

Abstract

The development of infective endocarditis and cardiac thrombus is a rare but serious complication in the newborn infant. Herein we report the use of recombinant tissue plasminogen activator in a term infant to successfully treat a Staphylococcal infective endocarditis vegetation that was unresponsive to antimicrobial therapy and not amenable to surgical therapy.

References

Anderson B, Urs P, Tudehope D, Ward C. The use of recombinant tissue plasminogen activator in the management of infective intracardiac thrombi in pre-term infants with thrombocytopaenia..Journal of Paediatrics and Child Health 2009;45:598–601.

Saiman L, Prince A, Gersony WM. Pediatric infective endocarditis in the modern era. J Pediatr 1993;122:847-53.

Stull TL, Lipuma JJ. (1992) Endocarditis in children. In: Kaye D (ed). Infective endocarditis. 2nd ed. New York, Raven Press, p.313-27.

Fleming RE, Barenkamp SJ, Jureidini SB. Successful treatment of a Staphylococcal endocarditis vegetation with tissue plasminogen activator. J. Pediatr. 1998; 132: 535–7.

Dajami AS, Taubert KA. (2001) Infected endocarditis in: Moss AJ, Adams FH, editors. Heart disease in infants, children and adolescents. 6th ed, vol 2. Philadelphia (PA): Lippincott Williams & Wilkins;. p.1297-1308.

Douglas JL, Dismukes WE. (1992) Surgical therapy of infective endocarditis on natural valves. In: Kaye D (ed). Infective endocarditis. 2nd ed. New York (NY): Raven Press; p. 397.

Nomura F, Penny DJ. Surgical intervention for infective endocarditis in infancy and childhood. Ann. Thorac. Surg. 1995; 60: 90–5.

Leaker M, Massicotte P, Brokker LA, Andrew M. Thrombolytic therapy in pediatric patients: a comprehensive review of the literature. Thromb Haemost 1996;76:132-4.

Nowak-Goth U, Auberger K, Halimeh S. Thrombolysis in newborns and infants. Thromb. Haemost. 1999; 82: 112–6.

Published
2018-03-15