Dermatofibrosarcoma Protuberans: A Rare Cause of Giant Breast Mass
Abstract
Dermatofibrosarcoma protuberans (DFSP) is a rare soft tissue tumor of dermis and subcutaneous tissue, mostly seen in trunk and extremities. Here we present a case of DFSP in the breast of a young women. A 26 years old female admitted to hospital with a 7 cm painless mass at right breast. Trucut biopsy reported spindle cell tumor. PET/CT and thorax CT revealed no metastases. Breast conserving surgery and sentinel lymph node biopsy was done. Pathological examination report was DFSP and reactive lymphadenopathy. Due to high recurrence rates in DFSP cases, wide local excision for acceptable oncologic margins and follow up is necessary.References
Darier J. Dermatofibromes progressifs et recidivants ou fibrosarcomes de la peau. Ann Dermatol Syph. 1924;5:545-62.
Pohlodek K, Mečiarová I, Grossmann P, Kinkor Z. Dermatofibrosarcoma protuberans of the breast: A case report. Oncol Lett. 2017;14(1):993-8.
Tse GM, Tan PH, Lui PC, Putti TC. Spindle cell lesions of the breast--the pathologic differential diagnosis. Breast Cancer Res Treat. 2008;109(2):199-207.
Al-Rahbi S, Al-Lawati T, Al-Kharusi S, Thomas S, Al-Harrasi K. Dermatofibrosarcoma Protuberans: A Rare Malignancy of the Breast. Oman Med J. 2015;30(5):378-81.
Bogucki B, Neuhaus I, Hurst EA. Dermatofibrosarcoma protuberans: a review of the literature. Dermatol Surg. 2012;38(4):537-51.
Fontecilla NM, Kittler NW, Geskin L, Samie FH, Niedt G, Imahiyerobo T, Schwartz G, Ingham M, Lewin JM. Recurrent dermatofibrosarcoma protuberans treated with neoadjuvant imatinib mesylate followed by Mohs micrographic surgery. JAAD Case Rep. 2017;3(6):467-469.
Sin FN, Wong KW. Dermatofibrosarcomaprotuberans of the breast: a case report. Clin Imaging. 2011;35:398–400.
Burud IAS, How NS, CheeWei G, Roslina S. Dermatofibrosarcoma Protuberance of the Breast:a Diagnostic Challenge Indian J Surg 2017;79(2):169–172.
Dragoumis DM, Katsohi LA, Amplianitis IK, Tsiftsoglou AP. Late local recurrence of dermatofibrosarcoma protuberans in the skin of female breast. World Journal of surgical oncology. 2010;3;8:48.
