Dioxin is an Insidious Toxin: The Role of Liposuction for the Blood Dioxin Levels

  • Bora Ozel Memorial Sisli Hospital Department of Plastic Reconstructive and Aesthetic Surgery
  • Seyhan Cenetoglu Gazi University Faculty of Medicine Department of Plastic Reconstructive and Aesthetic Surgery
  • Ayse Sencan Bagcilar Training and Research Hospital Department of Hand Surgery
Keywords: Adipose tissue, dioxin, liposuction, toxic effects


Background: Dioxins are chemicals which remain intact in the environment for long periods, accumulate in fat tissues of living organisms and are toxic to humans. The aim of this study is determining the concentration of dioxin which passes from the adipose tissues to the bloodstream by means of liposuction, and comparing the results with the existing dioxin level in the blood in order to take certain precautions according to the obtained results. Methods: From May 2012 to April 2013, blood values of 9 female patients, who underwent liposuction, were examined. Their blood samples were collected on three stages, once before the surgery, once on the day after the surgery and finally 3 weeks after the surgery. It was a tumescent liposuction performed on abdominal area. Dioxin levels were also measured from the adipose tissue obtained through liposuction. The dioxin toxic levels were measured by gas chromatography / tandem mass spectrometry. Results: The results have demonstrated that serum concentration of dioxin significantly decreased after liposuction. (Preoperative 0.23, postoperative 1 0,17, postoperative 30 0.15) (p=0.007). Liposuction leads to a redistribution of dioxins and to a moderate decrease of their blood concentration. Epinephrine, a potent vasoconstrictor added to infiltrate solution, may inhibit dioxin uptake into the system circulation. Conclusions: The results of this study have demonstrated that liposuction has a reducing function in blood dioxin levels. We believe that liposuction leads to a redistribution of dioxin and to a moderate decrease in the blood concentration which is possible to help to reduce toxic effects. This study is very important since it is the first report on dioxin contamination in human blood in Turkish society as well.


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