Dioxin is an Insidious Toxin: The Role of Liposuction for the Blood Dioxin Levels

  • Bora Ozel Memorial Sisli Hospital Department of Plastic Reconstructive and Aesthetic Surgery
  • Seyhan Cenetoglu Gazi University Faculty of Medicine Department of Plastic Reconstructive and Aesthetic Surgery
  • Ayse Sencan Bagcilar Training and Research Hospital Department of Hand Surgery
Keywords: Adipose tissue, dioxin, liposuction, toxic effects

Abstract

Background: Dioxins are chemicals which remain intact in the environment for long periods, accumulate in fat tissues of living organisms and are toxic to humans. The aim of this study is determining the concentration of dioxin which passes from the adipose tissues to the bloodstream by means of liposuction, and comparing the results with the existing dioxin level in the blood in order to take certain precautions according to the obtained results. Methods: From May 2012 to April 2013, blood values of 9 female patients, who underwent liposuction, were examined. Their blood samples were collected on three stages, once before the surgery, once on the day after the surgery and finally 3 weeks after the surgery. It was a tumescent liposuction performed on abdominal area. Dioxin levels were also measured from the adipose tissue obtained through liposuction. The dioxin toxic levels were measured by gas chromatography / tandem mass spectrometry. Results: The results have demonstrated that serum concentration of dioxin significantly decreased after liposuction. (Preoperative 0.23, postoperative 1 0,17, postoperative 30 0.15) (p=0.007). Liposuction leads to a redistribution of dioxins and to a moderate decrease of their blood concentration. Epinephrine, a potent vasoconstrictor added to infiltrate solution, may inhibit dioxin uptake into the system circulation. Conclusions: The results of this study have demonstrated that liposuction has a reducing function in blood dioxin levels. We believe that liposuction leads to a redistribution of dioxin and to a moderate decrease in the blood concentration which is possible to help to reduce toxic effects. This study is very important since it is the first report on dioxin contamination in human blood in Turkish society as well.

References

Lindén J, Lensu S, Tuomisto J, Pohjanvirta R. Dioxins , the aryl hydrocarbon receptor and the central regulation of energy balance Frontiers in Neuroendocrinology 2010;31:452–78.

Davy CW. Legislation with respect to dioxins in the workplace 2004;30:219–33.

Yoshida R, Ogawa Y. p -dioxin : An Application of Oxidative Stress Markers to Cancer Risk Assessment of Dioxins 2000:5–14.

Kang HK, Watanabe KK, Breen J, Remmers J, Conomos MG, Stanley J. Dioxins and Dibenzofurans in Adipose Tissue of US Vietnam Veterans and Controls 1991;81.

Sorg O, Zennegg M, Schmid P, Fedosyuk R, Valikhnovskyi R, Gaide O, et al. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites. Lancet 2009;374:1179–85.

Todaka T, Hirakawa H, Kajiwara J, Onozuka D, Sasaki S, Furue M. Chemosphere Concentrations of polychlorinated dibenzo-p-dioxins , polychlorinated dibenzofurans , and polychlorinated biphenyls in blood and breast milk collected from pregnant women in Sapporo City , Japan. Chemosphere 2011;85:1694–700.

Steenland K, Deddens J, Piacitelli L. Risk assessment for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) based on an epidemiologic study. Am J Epidemiol 2001;154:451–8.

Muenyi CS, Carrion SL, Jones LA, Kennedy LH, Slominski AT. Effects of ın utero exposure of C57BL/6J Mice 2,3,7,8- Tetrachlorodibenzo p -dioxin on Epidermal Permeability Barrier Development and Function. Environ Health Perspect 2014;122:1052–9.

Dioxin: Disposition and pharmacokinetics. Review 2003 December 1-114. Avaible from:

https://cfpub.epa.gov/ncea/iris_drafts/dioxin/nas-review/pdfs/part2/dioxin_pt2_ch01_dec2003.pdf.

Schecter A, Birnbaum L, Ryan JJ, Constable JD. Dioxins: an overview. Environ Res 2006;101:419–28.

Matsumura F. On the significance of the role of cellular stress response reactions in the toxic actions of dioxin. Biochem Pharmacol 2003;66:527–40.

Hahn ME. Aryl hydrocarbon receptors: diversity and evolution. Chem Biol Interact 2002;141:131–60.

Warner M, Eskenazi B, Mocarelli P, Gerthoux PM, Samuels S, Needham L, et al. Serum Dioxin Concentrations and Breast Cancer Risk in the Seveso Women’s Health Study. Environ Health Perspect 2002;110:625–8.

Baan R, Grosse Y, Straif K, Secretan B, El Ghissassi F, Bouvard V, et al. A review of human carcinogens—Part F: Chemical agents and related occupations. Lancet Oncol 2009;10:1143–4.

R.J.Rohrich SJB. Is liposuction safe. Plast Reconstr Surg 1999;104:819–26.

Kokichi arisawa, Hideo takeda H mikasa. Background exposure to PCDDs PCDFs PCBs and its potential health efffects : a review of epidemiologic studies. J Med Investig 2005;52:10–21.

Moser GA, Mclachlan MS. A non-absorbable dietary fat substitute enhances elimination of persistent lipophilic contaminants in humans. Chemosphere 1999;39:1513–21.

Iverson RE, Pao VS. MOC-PS(SM) CME article: liposuction. Plast Reconstr Surg 2008;121:1–11.

Kenkel JM, Lipschitz AH, Luby M, Kallmeyer I, Sorokin E, Appelt E, et al. Hemodynamic Physiology and Thermoregulation in Liposuction. Plast Reconstr Surg 2004;114:503–13.

Viluksela M, Duong T V, Stahl BU, Li X, Tuomisto J, Rozman KK. Toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in two substrains of male Long-Evans rats after intravenous injection. Fundam Appl Toxicol 1996;31:184–91.

Voorspoels S, Covaci A, Maervoet J, Schepens P. Relationship between age and levels of organochlorine contaminants in human serum of a belgian population. Chemosphere 2002;69:22–9.

Wolff MS, Anderson HA, Fat B, Cancer D, Biomark E. Correspondence re : J . M . Schildkraut et al ., Environmental Contaminants and Body Fat Distribution . Cancer Epidemiol . Biomark . Prev1999: 179:951–2.

Schildkraut JM, Demark-Wahnefried W, DeVoto E, Hughes C, Laseter JL, Newman B. Environmental contaminants and body fat distribution. Cancer Epidemiol Biomarkers Prev 1999;8:179–83.

Hue O, Marcotte J, Berrigan F, Doré J, Marceau P, Tremblay A, et al. Increased Plasma Levels of Toxic Pollutants Accompanying Weight Loss Induced by Hypocaloric Diet or by Bariatric Surgery 2006:1145–54.

Mauer MM, Harris RB, Bartness TJ. The regulation of total body fat: lessons learned from lipectomy studies. Neurosci Biobehav Rev 2001;25:15–28.

Kim M-J, Marchand P, Henegar C, Antignac J-P, Alili R, Poitou C, et al. Fate and complex pathogenic effects of dioxins and polychlorinated biphenyls in obese subjects before and after drastic weight loss. Environ Health Perspect 2011;119:377–83.

A.Matarasso, R.W.Kim JGK. The impact if liposuction on body fat. Plast Reconstr Surg 1998;102:1686–9.

Esposito K, Giugliano G, Scuderi N, Giugliano D. Role of adipokines in the obesity-inflammation relationship: the effect of fat removal. Plast Reconstr Surg 2006;118:1048–57; discussion 1058–9.

Rigotti G, Marchi A, Stringhini P, Baroni G, Galiè M, Molino AM, et al. Determining the oncological risk of autologous lipoaspirate grafting for post-mastectomy breast reconstruction. Aesthetic Plast Surg 2010;34:475–80.

Pearl R a, Leedham SJ, Pacifico MD. The safety of autologous fat transfer in breast cancer: lessons from stem cell biology. J Plast Reconstr Aesthet Surg 2012;65:283–8.

Lohsiriwat V, Curigliano G, Rietjens M, Goldhirsch A, Yves J. Autologous fat transplantation in patients with breast cancer : “ silencing ” or “ fueling ” cancer recurrence ? The Breast 2011;20:351–7.

Vona-Davis L, Rose DP. Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocr Relat Cancer 2007;14:189–206.

Perrot P, Rousseau J, Bouffaut A-L, Rédini F, Cassagnau E, Deschaseaux F, et al. Safety concern between autologous fat graft, mesenchymal stem cell and osteosarcoma recurrence. PLoS One 2010;5:e10999.

Cok ismet, Donmez M, Satiroglu H.Aydinuraz, Kabukcu, Henkel I. levels of dioxin-like PCB congeners in adipose tissue of Turkish men. JPHARMSCİ 2006:7–10.

Shen H, Han J, Tie X, Xu W, Ren Y, Ye C. Polychlorinated dibenzo-p-dioxins/furans and polychlorinated biphenyls in human adipose tissue from Zhejiang Province, China. Chemosphere 2009;74:384–8.

Published
2018-12-20
Section
Original Research